Association study of theTNF-α−1031T/C andVEGF + 450G/C polymorphisms with susceptibility to endometriosis

Kioomars Saliminejad, Toktam Memariani, Ali M Ardekani, Koorosh Kamali, Haleh Edalatkhah, Zhamak Pahlevanzadeh, Hamid Reza Khorram Khorshid
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(11) , pp. 974–977 · doi:10.3109/09513590.2013.824956 · PMID:23952049 · W2017859472
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This study investigated the association of TNF-α -1031T/C and VEGF +450G/C polymorphisms with endometriosis in an Iranian population, finding the TNF-α -1031C allele associated with reduced susceptibility.

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Abstract

Tumor necrosis factor-α (TNF-α), a multifunctional proinflammatory cytokine, and vascular endothelial growth factor (VEGF), a major mediator of angiogenesis and vascular permeability, have been investigated in endometriosis patients of different populations. This study was carried out to investigate whether the two polymorphisms, TNF-α -1031T/C and VEGF +450G/C are associated with susceptibility to endometriosis in an Iranian population. Totally, 135 women with diagnosis of endometriosis and 173 women with no evidence of the disease were included in this study. The -1031T/C and +450G/C polymorphisms were assessed by PCR-RFLP analysis, using the two restriction enzymes BbsI and BsmFI, respectively. The frequencies of the TNF-α -1031TC genotype (p = 0.038) and the -1031 C allele (p = 0.048) were significantly lower in patients than control group. In contrast, no significant differences in the genotype and allele frequencies of the VEGF +450G/C polymorphism were found between the case and control groups. Our results suggest that the TNF-α -1031T/C polymorphism was associated with susceptibility to endometriosis in Iranian population, and the -1301C allele may have a protective role in development of endometriosis; On the contrary, we find no association between the VEGF +450G/C polymorphism and risk of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Polymorphism, Single Nucleotide Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A 5' Untranslated Regions Adult Alleles Body Mass Index Case-Control Studies Endometriosis Endometriosis Endometriosis Endometriosis Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Infertility, Female Infertility, Female

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