Interleukin 1 alpha ( IL1A ) polymorphisms and risk of endometriosis in Iranian population: a case-control study

Azadeh Badie, Badie A, Kioomars Saliminejad, Iman Salahshourifar, Salahshourifar I, Hamid Reza Khorram Khorshid, Khorram Khorshid HR
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 36(2) , pp. 135–138 · doi:10.1080/09513590.2019.1631790 · PMID:31248297 · W2954345528
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This study found the IL1A rs2856836 T/C SNP and the C allele were significantly associated with increased endometriosis risk in Iranian women.

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Abstract

Endometriosis is one of the most common gynecological diseases and a major cause of pain and infertility. It is influenced by genetic, epigenetic, and environmental factors. Recently, genome-wide association studies have revealed a strong association between IL1A single nucleotide polymorphisms (SNPs) and increased risk of endometriosis in Japanese women. The aim of the present study was to evaluate the association of three IL1A SNPs, rs17561, rs1304037, and rs2856836 with the risk of endometriosis in Iranian population. Totally, 105 women with diagnosis of endometriosis and 102 healthy women as control group were included. Three SNPs of the IL1A, rs17561 G/T, rs1304037 A/G, and rs2856836 T/C, were genotyped by PCR and RFLP. The rs2856836 TC genotype was significantly higher (p = .002; OR = 3.1, 95% CI: 1.5–6.5) in the patients (28.1%) than the control group (12.7%). The rs2856836 CC genotype was significantly higher (p = .047; OR = 2.3, 95% CI: 1.0–5.3) in the patients (17.5%) than the control group (10.8%). The rs2856836 C allele was significantly higher (p = .001; OR = 2.2, 95% CI: 1.4–3.6) in the patients (31.6%) than the control group (17.2%). The IL1A rs2856836 T/C SNP was associated with susceptibility to endometriosis and the rs2856836 C allele may increase the risk of endometriosis in Iranian women.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Interleukin-1alpha Adult Alleles Case-Control Studies Endometriosis Female Gene Frequency Genotype Humans Interleukin-1alpha Iran Middle Aged Polymorphism, Single Nucleotide Young Adult

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