Association of common variations of the E-cadherin with endometriosis

Kioomars Saliminejad, Haleh Edalatkhah, Koorosh Kamali, Toktam Memariani, Mahbobeh Nasiri, Mitra Saket, Hamid Reza Khorram Khorshid
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2015 · vol. 31(11) , pp. 899–902 · doi:10.3109/09513590.2015.1101436 · PMID:26484421 · W2190713879
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This study found that the CDH1 +54T allele was less common in Iranian endometriosis patients, suggesting a potential protective role in disease susceptibility.

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Abstract

Endometriosis is a polygenic and multifactorial disease. E-cadherin (CDH1) gene encodes an epithelial cell-cell adhesion glycoprotein that modulates a wide variety of processes, including cell polarization, migration and cancer metastasis. Decreased expression of CDH1 in epithelial cells in peritoneal endometriosis has been reported in advanced stages of endometriotic lesions. We investigated the CDH1 -160C/A and +54C/T variations with susceptibility to endometriosis in an Iranian population. In this case-control study, 149 patients with endometriosis (stages I-IV) and 151 healthy women as controls were included. Genotyping was performed using PCR-RFLP method. A p value of <0.05 was considered statistically significant. The CDH1 + 54TT genotype was significantly lower (p = 0.012; OR = 0.30, 95% CI: 0.12-0.77) in the patients (11.6%) than the control group (26.7%). The CDH1 + 54T allele was significantly lower (p = 0.001; OR = 0.55, 95% CI: 0.38-0.77) in the cases (35.7%) compared with the control group (50.3%). No association was found between CDH1 - 160C/A polymorphism and endometriosis. The CDH1 +54C/T was associated with susceptibility to endometriosis in Iranian population, and +54T allele may have a protective role in progression of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cadherins Endometriosis Adult Alleles Antigens, CD Cadherins Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Genotype Humans Iran Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Young Adult

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