Translational Applications of Linear and Circular Long Noncoding RNAs in Endometriosis

Xiyin Wang, Luca Parodi, Shannon M. Hawkins
International journal of molecular sciences · 2021 · vol. 22(19) , pp. 10626 · doi:10.3390/ijms221910626 · PMID:34638965 · PMC8508676 · W3202684999
review OA: gold CC0 ⤵ 1 in-corpus citation
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This review explores the formation, expression, and function of long noncoding and circular long noncoding RNAs in endometriosis, highlighting their potential for improved diagnostics and therapeutics.

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Abstract

Endometriosis is a chronic gynecologic disease that negatively affects the quality of life of many women. Unfortunately, endometriosis does not have a cure. The current medical treatments involve hormonal manipulation with unwanted side effects and high recurrence rates after stopping the medication. Sadly, a definitive diagnosis for endometriosis requires invasive surgical procedures, with the risk of complications, additional surgeries in the future, and a high rate of recurrence. Both improved therapies and noninvasive diagnostic tests are needed. The unique molecular features of endometriosis have been studied at the coding gene level. While the molecular components of endometriosis at the small RNA level have been studied extensively, other noncoding RNAs, such as long intergenic noncoding RNAs and the more recently discovered subset of long noncoding RNAs called circular RNAs, have been studied more limitedly. This review describes the molecular formation of long noncoding and the unique circumstances of the formation of circular long noncoding RNAs, their expression and function in endometriosis, and promising preclinical studies. Continued translational research on long noncoding RNAs, including the more stable circular long noncoding RNAs, may lead to improved therapeutic and diagnostic opportunities.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis RNA, Circular RNA, Circular RNA, Long Noncoding RNA, Long Noncoding RNA Processing, Post-Transcriptional Biomarkers Biomarkers Endometriosis Female Gene Expression High-Throughput Nucleotide Sequencing High-Throughput Nucleotide Sequencing Humans Quality of Life RNA, Circular RNA, Circular RNA, Long Noncoding RNA, Long Noncoding

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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