Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling

Peng Chen, Ramanaiah Mamillapalli, Shutaro Habata, Hugh S Taylor
Molecular and cellular biochemistry · 2021 · vol. 476(4) , pp. 1717–1727 · doi:10.1007/s11010-020-04012-1 · PMID:33428059 · W3120130894
article OA: closed CC0 ⤵ 12 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis stromal cells promote bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling, potentially aiding immune evasion.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The study investigated whether endometriosis-derived stromal cells regulate the differentiation of bone marrow-derived cells (BMDCs) that engraft endometriotic lesions, using in-vitro co-culture of BMDCs with stromal cells from endometriosis patients versus control endometrium and in-vivo evaluation in a murine endometriosis model. BMDCs cocultured with endometriosis stromal cells showed increased mRNA and protein levels of stromal, epithelial, and leukocyte markers (vimentin and cytokeratin) and a key immune checkpoint, PD-1, and PD-1 induction in engrafted BMDCs was confirmed in vivo. Inhibition of the CXCR4 receptor with AMD3100 blocked PD-1 expression in BMDCs, implicating CXCL12-dependent paracrine signaling. The paper does not directly measure functional consequences of PD-1 induction for T cell activity within this experimental setup, beyond discussing a plausible immune-tolerance mechanism. This paper is centrally about endometriosis — it shows endometriosis stromal cells promote BMDC differentiation and induce PD-1 via CXCL12/CXCR4 signaling, linking BMDC remodeling to immune evasion in endometriotic lesions.

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Condition tags

endometriosis

MeSH descriptors

Bone Marrow Cells Cell Differentiation Endometriosis Gene Expression Regulation Mesenchymal Stem Cells Paracrine Communication Programmed Cell Death 1 Receptor Adolescent Adult Bone Marrow Cells Bone Marrow Cells Coculture Techniques Endometriosis Endometriosis Female Humans Mesenchymal Stem Cells Middle Aged Programmed Cell Death 1 Receptor Stromal Cells

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