Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment

Rômulo Medina de Mattos, Mattos RM, Daniel Escorsim Machado, Machado DE, Jamila Alessandra Perini, Jéssica Alessandra-Perini, Alessandra-Perini J, Meireles da Costa NO, Nathália de Oliveira Meireles da Costa, Adalgisa Felippe da Rocha de Oliveira Wiecikowski, Adalgisa Felippe Wiecikowski, Wiecikowski AFDRO, Kátia Maria dos Santos Cabral, Katia Maria Dos Santos Cabral, Cabral KMDS, Christina Maeda Takiya, Carvalho RS, Renato Sampaio Carvalho, Renato S. Carvalho, Nasciutti LE, Luiz Eurico Nasciutti
Molecular and cellular endocrinology · 2019 · vol. 486 , pp. 1–10 · doi:10.1016/j.mce.2019.02.007 · PMID:30753853 · W2913150157
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Galectin-3 deficiency and Gal-3 carbohydrate recognition domain treatment reduced endometriotic lesion size, vascularization, and macrophage infiltration in mice.

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Abstract

This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Then, WT mice were treated with Gal3C for 15 days. Gal-3 deficiency and Gal3C treatment significantly impaired endometriosis development. A significant decrease in lesions implantation and size, VEGF and VEGFR-2 expression, vascular density and macrophage distribution were observed in Gal-3 absence or inhibition. A greater presence of iNOS positive cells was observed in knockout mice lesions, while the presence of Arginase positive cells was higher in the WT animal lesions. In addition, COX-2 and TGFb1 were reduced by Gal3C treatment. Data showed here indicate a relevant role of Gal-3 in endometriosis development and highlight a target of endometriosis treatment using Gal-3 inhibitor.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Galectin 3 Molecular Targeted Therapy Animals Biomarkers Biomarkers Endometriosis Endometrium Endometrium Endometrium Female Galectin 3 Galectin 3 Inflammation Inflammation Macrophages Macrophages Macrophages Mice, Inbred BALB C

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