microRNAs and angiogenesis in endometriosis

Josep Marí‐Alexandre, Marí-Alexandre J, Josep Marí-Alexandre, García-Oms J, Javier García-Oms, Moisés Barceló‐Molina, Barceló-Molina M, Moisés Barceló-Molina, Juan Gilabert-Aguilar, Gilabert-Aguilar J, Estellés A, Amparo Estellés, Aitana Braza‐Boïls, Aitana Braza-Boíls, Juan Gilabert–Estellés, Juan Gilabert-Estellés
Thrombosis research · 2015 · vol. 135 , pp. S38–S40 · doi:10.1016/s0049-3848(15)50439-8 · PMID:25903532 · W2057997816
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This paper investigates the role of microRNAs in angiogenesis, the process of new blood vessel formation, within the context of endometriosis.

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Abstract

miRNAs function as important regulators of a wide range of cellular processes, such as angiogenesis and fibrinolysis, by postranscriptional modulation of gene expression. We present a review on the role of miRNAs and angiogenesis in endometriosis. Endometriosis, defined as the implantation of endometrial tissue outside the uterine cavity, is one of the most frequent benign gynecological diseases and it has important consequences on the quality of life and fertility of patients. Similarly to tumor metastasis, the ectopic endometrium acquires the capability to adhere, proliferate and infiltrate the extracellular matrix. Endometriosis is a multifactorial and polygenic disease in which angiogenesis and proteolysis may be involved, and emerging data provide evidence that a dysregulation of miRNA expression may be implicated in these processes. The detection of circulating miRNAs in plasma and other body fluids and their relative stability has raised the possibility that they might serve as non-invasive biomarkers for the diagnosis of the disease. On the other hand, the development of therapies that might block the expression or mimic the functions of miRNAs could represent new therapeutic strategies for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis MicroRNAs Models, Cardiovascular Neovascularization, Pathologic Biomarkers Biomarkers Endometriosis Female Humans MicroRNAs Neovascularization, Pathologic

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (26)

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