Decreased expression of miR-200a and miR-223-3p in endometriosis during the secretory phase of menstrual cycle: Insights from a case-control study on molecular biomarkers and disease-related infertility

Yasaman Nazari Hagh, Mohamadreza Ahmadifard, Sedigheh Esmaelzadeh, Soheila Abbaszadeh, Soheila Abbaszadeh Godarzi, Naser Shokrzadeh
International journal of reproductive biomedicine · 2025 · vol. 22(12) , pp. 1003–1014 · doi:10.18502/ijrm.v22i12.18066 · PMID:39968362 · W4407265089
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case-control study found decreased expression of miR-200a and miR-223-3p in the eutopic endometrium of women with endometriosis compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This case-control study investigated molecular biomarkers of infertility in women with endometriosis by measuring the expression of miR-200a and miR-223-3p during the secretory phase of the menstrual cycle. Using participants grouped by disease status, the authors found decreased expression of both miR-200a and miR-223-3p in endometriosis compared with controls. They interpret these differential miRNA levels as potentially relevant to disease-related infertility, while the study’s caveats include its case-control design and the relatively limited sample-level context implied by the publication record rather than broader validation. This paper is centrally about endometriosis — focusing on decreased miR-200a and miR-223-3p expression during the secretory phase and its relation to infertility.

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Abstract

Background: Endometriosis (EM) is a condition that causes infertility with decreasing uterine receptivity. It is reported that it affects about 20–25% of all infertile women. Some genetic markers play a crucial role in pathogenesis and infertility. Objective: This study investigates the role of miR-200a and miR-223-3p in embryo implantation and their association with EM-related infertility. Materials and Methods: In this case-control study, 36 women who referred to the Center for Research on Reproductive Health and Infertility of Babol University of Medical Sciences and Fatemeh Al-Zahra Infertility Specialized Treatment Center in Babol, Iran between June 2022 and July 2023 were evaluated. Participants were divided into 2 EM and control groups (n = 18/each). Endometrial samples were collected from participants between 17th and 24th days of their menstrual cycle. Histopathological examination (hematoxylin and eosin and periodic acid schiff) was performed to confirm the secretory stage, and miR-200a and miR-223-3p expressions were analyzed by quantitative reverse transcriptase-polymerase chain reaction. Results: Histological analysis confirmed that both groups were in the secretory stage. Additionally, miRNA expression results showed a significant decrease in the miR-200a and miR-223-3p expression levels in EM group compared to control group. The expression level of miR-223-3p and miR-200a in the eutopic endometrial tissue of women with EM was notably lower than those in the control group. Conclusion: Our results suggest that miR-200a and miR-223-3p are involved in the EM pathogenesis, while other genes and signaling pathways are probably involved in the implantation failure.

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endometriosisinfertility

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