Preventive effects of danazol on endometrial carcinogenesis in mice

Kenji Niwa, Midori Hashimoto, Shigeo Morishita, Yasuhiro Yokoyama, Zenglin Lian, Keiko Tagami, Hideki Mori, Teruhiko Tamaya
In: Cancer Letters · 2000 · vol. 158(2) , pp. 133–139 · doi:10.1016/s0304-3835(00)00497-3 · PMID:10960762 · W2084065351
article OA: closed CC0 ⤵ 5 in-corpus citations
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This study investigated the preventive effects of danazol on endometrial carcinogenesis in mice and found it reduced tumor development.

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Abstract

Short and long-term experiments were designed to determine effects of danazol on estrogen-related endometrial carcinogenesis in mice. The short-term assays showed that danazol decreased expression levels of c-fos/jun mRNA and their oncoproteins induced by estradiol-17beta (E2). For the long-term assay, 85 female ICR mice were given N-methyl-N-nitrsourea solution into their uterine corpora. The animals were divided into three groups as follows: Group 1, E2-diet (5 ppm) plus danazol (2 mg/body (s.c.), every 4 weeks); Group 2, E2-diet alone, Group 3, basal diet alone. At 30 weeks, incidences of atypical and complex endometrial hyperplasia were significantly decreased by danazol-treatment. These results suggest that danazol has preventive effects on estrogen-related endometrial carcinogenesis in mice, through the suppression of estrogen-induced c-fos/jun-expression.

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