Preventive effects of danazol on endometrial carcinogenesis in mice

Kenji Niwa, K Niwa, Midori Hashimoto, M Hashimoto, S Morishita, Shigeo Morishita, Y Yokoyama, Yasuhiro Yokoyama, Z Lian, Zenglin Lian, Keiko Tagami, K Tagami, H Mori, Hideki Mori, Teruhiko Tamaya, T Tamaya
Cancer letters · 2000 · vol. 158(2) , pp. 133–139 · doi:10.1016/s0304-3835(00)00497-3 · PMID:10960762 · W2084065351
Lab / animal OA: closed CC0 ⤵ 5 in-corpus citations
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This study investigated the preventive effects of danazol on endometrial carcinogenesis in mice and found it reduced tumor development.

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Abstract

Short and long-term experiments were designed to determine effects of danazol on estrogen-related endometrial carcinogenesis in mice. The short-term assays showed that danazol decreased expression levels of c-fos/jun mRNA and their oncoproteins induced by estradiol-17beta (E2). For the long-term assay, 85 female ICR mice were given N-methyl-N-nitrsourea solution into their uterine corpora. The animals were divided into three groups as follows: Group 1, E2-diet (5 ppm) plus danazol (2 mg/body (s.c.), every 4 weeks); Group 2, E2-diet alone, Group 3, basal diet alone. At 30 weeks, incidences of atypical and complex endometrial hyperplasia were significantly decreased by danazol-treatment. These results suggest that danazol has preventive effects on estrogen-related endometrial carcinogenesis in mice, through the suppression of estrogen-induced c-fos/jun-expression.

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MeSH descriptors

Danazol Endometrial Neoplasms Estrogen Antagonists Administration, Oral Alkylating Agents Alkylating Agents Animals Danazol Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Estradiol Estradiol Estrogen Antagonists Female Gene Expression Regulation, Neoplastic Gene Expression Regulation, Neoplastic Immunohistochemistry Methylnitrosourea Methylnitrosourea

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