Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis

Luana Grupioni Lourenço Antonio, Luana Grupioni Lourenço Antônio, Juliana Meola, Ana Carolina Japur de Sá Rosa e Silva, Ana Carolina Japur de Sá Rosa-E-Silva, Antônio Alberto Nogueira, Antonio Alberto Nogueira, Francisco José Cândido dos Reis, Francisco José Candido Dos Reis, Omero Benedicto Poli‐Neto, Júlio César Rosa e Silva
International journal of molecular sciences · 2023 · vol. 24(5) , pp. 4434 · doi:10.3390/ijms24054434 · PMID:36901866 · W4321787636
article OA: gold CC0 ⤵ 10 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that superficial peritoneal endometriosis exhibits distinct gene and microRNA expression patterns related to adhesion and apoptosis compared to deep infiltrating endometriosis and ovarian endometrioma.

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Abstract

We aim to investigate the expression of genes (MAPK1 and CAPN2) and microRNAs (miR-30a-5p, miR-7-5p, miR-143-3p, and miR-93-5p) involved in adhesion and apoptosis pathways in superficial peritoneal endometriosis (SE), deep infiltrating endometriosis (DE), and ovarian endometrioma (OE), and to evaluate whether these lesions share the same pathophysiological mechanisms. We used samples of SE (n = 10), DE (n = 10), and OE (n = 10), and endometrial biopsies of these respective patients affected with endometriosis under treatment at a tertiary University Hospital. Endometrial biopsies collected in the tubal ligation procedure from women without endometriosis comprised the control group (n = 10). Quantitative real-time polymerase chain reaction was performed. The expression of MAPK1 (p < 0.0001), miR-93-5p (p = 0.0168), and miR-7-5p (p = 0.0006) was significantly lower in the SE group than in the DE and OE groups. The expression of miR-30a (p = 0.0018) and miR-93 (p = 0.0052) was significantly upregulated in the eutopic endometrium of women with endometriosis compared to the controls. MiR-143 (p = 0.0225) expression also showed a statistical difference between the eutopic endometrium of women with endometriosis and the control group. In summary, SE showed lower pro-survival gene expression and miRNAs involved in this pathway, indicating that this phenotype has a different pathophysiological mechanism compared to DE and OE.

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Condition tags

mesh:D004715endometriosisdie_deep_infiltratingendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs MicroRNAs Apoptosis Apoptosis

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