Endometriosis, Pain and Mental Health.

Bernarda Škegro, Škegro B, Bjedov S, Sarah Bjedov, Mikuš M, Mislav Mikuš, Mustač F, Filip Mustač, Joško Lešin, Lešin J, Matijević V, Valentina Matijević, Ćorić M, Mario Ćorić, Elveđi Gašparović V, Vesna Elveđi Gašparović, Medić F, Filip Medić, Vesna Sokol Karadjole
Psychiatria Danubina · 2021 · vol. 33(Suppl 4) , pp. 632–636 · PMID:34718292 · W3209070342
article OA: green CC0 ⤵ 33 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study assessed quality of life and mental health in 79 endometriosis patients, finding significant depressive, anxious, and stress symptoms and complex correlations between these and pain, infertility, and overall health.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

This observational cross-sectional study assessed health-related quality of life and mental health in 79 women with endometriosis, using the Endometriosis Health Profile (EHP-5), the Depression Anxiety Stress Scales (DASS-21), and a Visual Analogue Scale for pain, with additional medical data retrieved from records. The study found that 44.3% had depressive symptoms, 25.3% anxiety, and 31.7% stress, with moderate correlations between EHP-5 and depression (r=0.515), stress (r=0.558), and VAS pain (r=0.565). It also reported weak positive associations between EHP-5 and anxiety and infertility, and moderate correlation between depression and infertility, with a stated limitation of the cross-sectional design implied by its snapshot assessment of relationships. This paper is centrally about endometriosis — it examines relationships among endometriosis-related quality of life, pain, infertility, and mental health outcomes.

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Abstract

BACKGROUND: Endometriosis is a chronic and progressive disease which can significantly affect a woman's personal, as well as intimate and professional aspects of life. The aim of this study was to asses health-related quality of life and mental health status in patients with endometriosis, investigating also their relationship with endometriosis-related comorbid symptoms and conditions, such as pain and infertility. SUBJECTS AND METHODS: An observational cross-sectional study involved 79 women with endometriosis. All patients filled the Endometriosis Health Profile (EHP-5), the Depression Anxiety Stress Scales (DASS-21) and the Visual Analogue Scale (VAS). Their medical data were retrieved from medical records. Data was analyzed using the SPSS 23.0 (IBM Corp., Armonk, NY). RESULTS: Of all the patients evaluated in our study, 44.3% presented depressive symptoms and 25.3% presented anxiety, while 31.7% reported stress symptoms. Moderate correlations were found between results on EHP-5 and depression (r=0.515), stress (r=0.558) and VAS score (r=0.565). Furthermore, weak positive relationship was observed between EHP-5 and anxiety (r=0.295) and infertility (r=0.267). Additionally, moderate correlation was found between depression and infertility (r=0.519), while there was weak association between VAS score and stress (r=0.236). CONCLUSIONS: This study showed complex relationships between symptoms and conditions manifesting in patients with endometriosis. Due to diversity of symptoms, potentially including mental health issues, it is important to emphasize the need for combined personalized treatment for these patients, taking into account both physical and psychological aspect of the disease.
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Abstract

Background: Endometriosis is a chronic and progressive disease which can significantly affect a woman's personal, as well as intimate and professional aspects of life. The aim of this study was to asses health-related quality of life and mental health status in patients with endometriosis, investigating also their relationship with endometriosis-related comorbid symptoms and conditions, such as pain and infertility. Subjects and methods: An observational cross-sectional study involved 79 women with endometriosis. All patients filled the Endometriosis Health Profile (EHP-5), the Depression Anxiety Stress Scales (DASS-21) and the Visual Analogue Scale (VAS). Their medical data were retrieved from medical records. Data was analyzed using the SPSS 23.0 (IBM Corp., Armonk, NY).

Results

Of all the patients evaluated in our study, 44.3% presented depressive symptoms and 25.3% presented anxiety, while 31.7% reported stress symptoms. Moderate correlations were found between results on EHP-5 and depression (r=0.515), stress (r=0.558) and VAS score (r=0.565). Furthermore, weak positive relationship was observed between EHP-5 and anxiety (r=0.295) and infertility (r=0.267). Additionally, moderate correlation was found between depression and infertility (r=0.519), while there was weak association between VAS score and stress (r=0.236).

Conclusions

This study showed complex relationships between symptoms and conditions manifesting in patients with endometriosis. Due to diversity of symptoms, potentially including mental health issues, it is important to emphasize the need for combined personalized treatment for these patients, taking into account both physical and psychological aspect of the disease. Publication types MeSH terms LinkOut - more resources Full Text Sources Medical

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Outcome instruments

EHP-30 VAS-pain

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Cross-Sectional Studies Depression Depression Female Humans Mental Health Pain Quality of Life

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (33)

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