The impact of early diagnosis of endometriosis on quality of life

Mania Kaveh, Maryam Nakhaee Moghadam, Mojtaba Safari, Shahla Chaichian, Abolfazl Mehdizadeh Kashi, Mahdi Afshari, Mehdi Afshari, Kambiz Sadegi
Archives of gynecology and obstetrics · 2025 · vol. 311(5) , pp. 1415–1421 · doi:10.1007/s00404-025-07999-4 · PMID:40188403 · PMC12033121 · W4409197117
article OA: gold CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This prospective study found that early or late diagnosis of endometriosis did not significantly impact patients' quality of life, though higher disease stages more negatively affected quality of life.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

In this longitudinal prospective study, 205 women with confirmed endometriosis were divided by diagnostic timing (≤5 years after symptom onset as early diagnosis vs >5 years as late diagnosis) and assessed with the Endometriosis Health Profile (EHP) questionnaire and visual analog scale (VAS) for pain before treatment and again 18 months after surgical or medical interventions. The authors found that quality-of-life scores improved in both early- and late-diagnosis groups without a significant difference between them (p = 0.303), while higher disease stage (ASRM stages 3–4) was associated with worse QoL before and after treatment compared with lower stages (1–2; P < 0.05). The main caveat is that the study’s conclusions rely on patients who completed treatment and questionnaire assessments and were excluded if diagnosis was not definitively confirmed or if major confounders/pregnancy occurred during follow-up. This paper is centrally about endometriosis — it evaluates whether early versus late diagnosis affects endometriosis-related quality of life over 18 months.

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Abstract

BACKGROUND: Endometriosis is one of the most common chronic diseases in women, with a prevalence of up to 10%. The disease particularly affects women of reproductive age. Endometriosis has a significant impact on the patient's quality of life (QoL). In the current study, we aimed to evaluate the role of early diagnosis of endometriosis on patients' QoL. METHODS: In this longitudinal prospective study, 205 women with endometriosis who were referred to the gynecology department of Amir al-Mominin Hospital (Zabol-Iran) in 2021 were evaluated. Patients were divided into two groups based on the time of diagnosis, including early diagnosis and late diagnosis. An Endometriosis Health Profile (EHP) questionnaire was used to collect information about QoL before and 18 months after treatment. Data were analyzed using SPSSv.26 software and significance level was considered less than 0.05. RESULTS: In both groups with early and late diagnosis, the QoL scores improved without significant difference (p = 0.303). There was a significant difference between lower stages (1 and 2) and higher stages (3 and 4) in terms of treatment effects on patients' QoL, and higher stages of endometriosis affected patients' QoL before and after treatment more than lower stages (P values < 0.05). CONCLUSION: Early or late diagnosis of endometriosis doesn't affect patients' QoL and patients benefit from treatment regardless of the time of diagnosis.

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Outcome instruments

EHP-30 VAS-pain

Condition tags

endometriosis

MeSH descriptors

Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Delayed Diagnosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

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References (26)

Cited by (2)

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