Chronic Pelvic Pain in Women with Endometriosis is Associated with Psychiatric Disorder and Quality of Life Deterioration

Raden Muharam, Titi Amalia, Gita Pratama, Achmad Kemal Harzif, Feranindhya Agiananda, Mila Maidarti, Mazaya Azyati, Kanadi Sumapraja, Hariyono Winarto, Budi Wiweko, Andon Hestiantoro, Eva Suarthana, Togas Tulandi
In: International Journal of Women's Health, Vol Volume 14, Pp 131-138 (2022) · 2022 · W4226486958
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study found that women with endometriosis experienced lower quality of life, particularly in aspects of pain and control, when reporting severe pain and psychiatric disorders.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

This cross-sectional study evaluated 160 women with medically diagnosed endometriosis to examine associations among pain intensity (VAS), psychiatric disorders (Mini-ICD via MINI International Neuropsychiatric Interview), and quality of life (EHP-30). Higher VAS pain scores and the presence of psychiatric disorder were both associated with higher EHP-30 scores, indicating deterioration in quality of life, with the strongest correlations between pain measures and the EHP-30 domains of pain and “control and powerlessness,” and VAS being higher in subjects with depression. A key limitation is that the design is cross-sectional, so it cannot establish temporal or causal relationships between pain, psychiatric disorder, and quality of life. This paper is centrally about endometriosis — it links chronic endometriosis-related pelvic pain and psychiatric disorder (including depression) to quality of life deterioration.

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Abstract

R Muharam,1 Titi Amalia,1 Gita Pratama,1 Achmad Kemal Harzif,1 Feranindhya Agiananda,2 Mila Maidarti,1 Mazaya Azyati,1 Kanadi Sumapraja,1 Hariyono Winarto,1 Budi Wiweko,1 Andon Hestiantoro,1 Eva Suarthana,3 Togas Tulandi3 1Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 2Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 3Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, CanadaCorrespondence: R MuharamDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia, Tel +62 812 85143491, Fax +1 205 975-6110, Email [email protected]: Endometriosis is a condition associated with pelvic pain, infertility, and possibly with decreased quality of life as well as psychiatric disorder. The purpose of our study was to evaluate the association between pain characteristic, psychiatric disorder, and quality of life in women with endometriosis.Methods: A cross-sectional study was done involving 160 women with medical diagnosis of endometriosis. Pain intensity was evaluated using Visual Analog Scale (VAS), Quality of Life with Endometriosis Health Profile (EHP-30), and psychologic condition with Mini International Neuropsychiatric Interview International Classification of Diseases (Mini-ICD).Results: VAS and psychiatric disorder were associated with higher EHP-30 score (β = 9.3 (95% CI: 7.15– 11.45; p < 0.001 and β = 28.51 (95% CI: 20.06– 36.05; p < 0.001), respectively) and hence, lower quality of life. The strongest correlation between VAS and EHP-30 was in pain (r=0.586; p< 0.001) and ‘control and powerlessness’ (r = 0.583; p < 0.001). VAS was also higher in subjects with depression (49.5 (25.4– 77.8) vs 34.4 (6.1– 74.6); p < 0.001).Conclusion: We conclude that severe endometriosis-related pain and the presence of psychiatric disorder were associated with lower quality of life. Comprehensive management of endometriosis is crucial to improve patients’ quality of life.Keywords: endometriosis, pain, depression, psychiatric disorder, quality of life
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International Journal of Women's Health (Feb 2022) Chronic Pelvic Pain in Women with Endometriosis is Associated with Psychiatric Disorder and Quality of Life Deterioration Abstract R Muharam,1 Titi Amalia,1 Gita Pratama,1 Achmad Kemal Harzif,1 Feranindhya Agiananda,2 Mila Maidarti,1 Mazaya Azyati,1 Kanadi Sumapraja,1 Hariyono Winarto,1 Budi Wiweko,1 Andon Hestiantoro,1 Eva Suarthana,3 Togas Tulandi3 1Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 2Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 3Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, CanadaCorrespondence: R MuharamDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia, Tel +62 812 85143491, Fax +1 205 975-6110, Email [email protected]: Endometriosis is a condition associated with pelvic pain, infertility, and possibly with decreased quality of life as well as psychiatric disorder. The purpose of our study was to evaluate the association between pain characteristic, psychiatric disorder, and quality of life in women with endometriosis.Methods: A cross-sectional study was done involving 160 women with medical diagnosis of endometriosis. Pain intensity was evaluated using Visual Analog Scale (VAS), Quality of Life with Endometriosis Health Profile (EHP-30), and psychologic condition with Mini International Neuropsychiatric Interview International Classification of Diseases (Mini-ICD).Results: VAS and psychiatric disorder were associated with higher EHP-30 score (β = 9.3 (95% CI: 7.15– 11.45; p < 0.001 and β = 28.51 (95% CI: 20.06– 36.05; p < 0.001), respectively) and hence, lower quality of life. The strongest correlation between VAS and EHP-30 was in pain (r=0.586; p< 0.001) and ‘control and powerlessness’ (r = 0.583; p < 0.001). VAS was also higher in subjects with depression (49.5 (25.4– 77.8) vs 34.4 (6.1– 74.6); p < 0.001).Conclusion: We conclude that severe endometriosis-related pain and the presence of psychiatric disorder were associated with lower quality of life. Comprehensive management of endometriosis is crucial to improve patients’ quality of life.Keywords: endometriosis, pain, depression, psychiatric disorder, quality of life

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Outcome instruments

EHP-30 VAS-pain

Condition tags

endometriosischronic_pelvic_paininfertility

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