Endometriosis of the appendix: prevalence, associated lesions, and proposal of pathogenetic hypotheses. A retrospective cohort study with prospectively collected data

Gabriele Centini, Alessandro Ginetti, Irene Colombi, Alberto Cannoni, Matteo Giorgi, Hélder Ferreira, Helder Ferreira, Francesco Fedele, Martina Pacifici, Francesco Giuseppe Martire, Errico Zupi, Lucia Lazzeri
Archives of gynecology and obstetrics · 2024 · vol. 310(3) , pp. 1669–1675 · doi:10.1007/s00404-024-07650-8 · PMID:39143333 · W4401576183
article OA: closed CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study found appendiceal endometriosis in 2.8% of patients undergoing endometriosis surgery, significantly associated with ovarian and bladder endometriosis, potentially due to endometrioma fluid shedding.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This monocentric retrospective cohort study with prospectively collected surgical data evaluated the prevalence of appendiceal endometriosis and its associations with other pelvic endometriosis localizations among 460 women undergoing laparoscopic endometriosis surgery, excluding those with prior appendectomy. Appendiceal endometriosis was found in 2.8% of cases, and when it was present there was a higher prevalence of concomitant ovarian endometriosis (53.9%) and bladder endometriosis (38.4%), with Poisson regression showing increased risks for ovarian and bladder involvement. Isolated ovarian endometriosis was also more frequently associated with appendiceal disease than isolated uterosacral ligament (USL) endometriosis or combined USL and ovarian disease. The paper’s main caveats include its single-center surgical cohort design and exclusion of women with previous appendectomy, and it proposes dissemination from endometrioma fluid shedding as a pathogenetic hypothesis, with relevance to counseling in that surgical context. This paper is centrally about endometriosis — it specifically analyzes prevalence, associated lesions, and pathogenesis hypotheses for appendiceal endometriosis.

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mesh:D004715endometriosis

MeSH descriptors

Appendix Appendix Appendix Appendix Appendix Appendix Appendix Appendix Appendix Appendix Appendix Appendix Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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