Appendiceal Endometriosis Presenting as Possible Cecal Mass
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This case report describes a 45-year-old female with appendiceal endometriosis presenting as a cecal mass, diagnosed pathologically after an ileocecectomy.
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Abstract
BACKGROUND: Endometriosis is endometrial tissue located outside of the uterus. Endometriosis is rarely found in the appendix and can present very similar to acute appendicitis and is often indistinguishable on physical exam and imaging. The diagnosis is typically made after an appendectomy on pathology. CASE SUMMARY: A 45-year-old female presented with right sided abdominal pain and CT revealed a possible cecal or appendiceal lesion. Colonoscopy revealed a submucosal non-obstructing cecal mass. In the operating room, the appendix was completely adherent to the cecum and a laparoscopic ileocecectomy was performed. Pathology revealed endometriosis of the appendix and cecum. DISCUSSION: Endometriosis of the appendix is a rare condition reported in less than 1% of females that is diagnosed after an appendectomy is performed for suspected appendicitis or other pathology. This diagnosis is made based on the finding of endometrial glands and stroma in the appendix. This can present as acute appendicitis or appendiceal or peri-appendiceal mass on imaging. When symptomatic, pain can align with the menstrual cycle and hemoperitoneum may be encountered intra-operatively. Treatment can be appendectomy, ileocecectomy, or right hemicolectomy if malignancy is suspected. In the patient we described, an ileocecectomy was performed with the intention of converting to a right hemicolectomy if the frozen section pathology had revealed malignancy. This case illustrates the importance of having a broad differential when diagnosing patients with abdominal pain, especially in women of childbearing age. CONCLUSION: Appendiceal endometriosis should be considered in females of childbearing age with abdominal pain or cecal/appendiceal mass on imaging.
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Cited by (9)
- Imaging Findings in Symptomatic Appendiceal Endometriosis: A Systematic Review of Case Reports 2025
- Endometriosis of the appendix: prevalence, associated lesions, and proposal of pathogenetic hypotheses. A retrospective cohort study with prospectively collected data 2024
- Surgical Management of Appendicular Endometriosis: A Series of Cases 2024
- Endometriosis in the Cecum: A Rare Clinical Entity 2023
- ENDOMETRIOSIS OF THE CECUM AND APPENDIX: REVIEW OF LITERATURE. 2023
- Appendiceal Endometriosis: A Comprehensive Review of the Literature 2023
- Immune and endocrine regulation in endometriosis: what we know 2023
- Endometriosis of the Appendix: When Appendicitis Is Less Than Straightforward 2023
- Two Cases of Endometriosis in the Cecum Detected by Contrast-enhanced Computed Tomography with Air/Carbon Dioxide Insufflation 2020
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:21:53.586419+00:00
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