Metabolomics for the identification of biomarkers in endometriosis

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This review summarizes identified endometriosis biomarkers from various bodily fluids, highlighting metabolomics' promise for non-invasive diagnosis and prognosis.

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This paper is a review that compiles metabolomics studies aimed at identifying biomarkers for endometriosis, using literature searches in PubMed from inception through December 2023 across multiple bodily fluids. The author summarizes reported metabolomic findings for potential biomarkers related to diagnosis, prognosis, mortality, and treatment response, highlighting metabolomics as a route to non-invasive approaches given limitations of invasive diagnostics. The key limitation explicitly noted in the review is that it is a synthesis of extracted studies rather than new experimental work, with no new biomarker validation reported. This paper is centrally about endometriosis — it specifically summarizes metabolomics-derived biomarkers across different body fluids.

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Abstract

BACKGROUND: Endometriosis affects the quality of life in women during their reproductive years, causing immense pain and can result in infertility. It is characterized by inflammation and the growth of the endometrium outside the uterine cavity. Metabolomics has the potential to resolve the major bottleneck of endometriosis which is delay in diagnosis due to the invasive diagnostic approach.In this review, the author has summarized the identified biomarkers of endometriosis from different bodily fluids. Metabolomics promises a non-invasive diagnostic approach for endometriosis that could aid in earlier diagnosis and prognosis. METHODS: Patients with endometriosis keywords were searched in correspondence with the assigned keywords, including metabolomics from PubMed, from its inception to Dec 2023. The relevant studies from this search were extracted and included in the study. RESULTS: This article provides information regarding metabolomics studies in endometrisis. CONCLUSIONS: We demonstrated that metabolomics is about to change the world of endometriosis by analyzing and detecting the diagnosis, prognosis, mortality and treatment response biomarkers.
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Abstract

Background Endometriosis affects the quality of life in women during their reproductive years, causing immense pain and can result in infertility. It is characterized by inflammation and the growth of the endometrium outside the uterine cavity. Metabolomics has the potential to resolve the major bottleneck of endometriosis which is delay in diagnosis due to the invasive diagnostic approach.In this review, the author has summarized the identified biomarkers of endometriosis from different bodily fluids. Metabolomics promises a non-invasive diagnostic approach for endometriosis that could aid in earlier diagnosis and prognosis.

Methods

Patients with endometriosis keywords were searched in correspondence with the assigned keywords, including metabolomics from PubMed, from its inception to Dec 2023. The relevant studies from this search were extracted and included in the study.

Results

This article provides information regarding metabolomics studies in endometrisis.

Conclusions

We demonstrated that metabolomics is about to change the world of endometriosis by analyzing and detecting the diagnosis, prognosis, mortality and treatment response biomarkers. Similar content being viewed by others Data availability Not applicable Code availability Not applicable

References

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Arch Gynecol Obstet 299(5):1501–1508 Funding Not applicable. Author information Authors and Affiliations Contributions Conception, design, analysis and interpretation of data, drafting the article, and final approval of the version to be published by Swarnima Pandey. Corresponding author Ethics declarations Conflict of interest Authors have no conflicts of interest to declare. Ethics approval Not applicable Consent to participate Not applicable Consent for publication Yes Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Pandey, S. Metabolomics for the identification of biomarkers in endometriosis. Arch Gynecol Obstet 310, 2823–2827 (2024). https://doi.org/10.1007/s00404-024-07796-5 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-024-07796-5

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endometriosis

MeSH descriptors

Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers

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