Lipidomic profiling of endometrial fluid in women with ovarian endometriosis†

Francisco Domínguez, Francisco Domı́nguez, Marcos Ferrando, Ferrando M, Díaz-Gimeno P, Patricia Díaz-Gimeno, Quintana F, Fernando Quintana, Gemma Fernández, Fernández G, Inés Castells, Castells I, Carlos Simón
Biology of reproduction · 2017 · vol. 96(4) , pp. 772–779 · doi:10.1093/biolre/iox014 · PMID:28340140 · W2596757932
article OA: bronze CC0 ⤵ 35 in-corpus citations
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This study performed untargeted lipidomic profiling of endometrial fluid, revealing 123 significantly differentially expressed metabolites between women with ovarian endometriosis and controls, with reduced saturated diacylglycerols and triacylglycerols in the endometriosis group.

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Abstract

The proteomic content of the endometrial fluid (EF) from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail.This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls.

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Condition tags

endometriosis

MeSH descriptors

Body Fluids Endometriosis Endometrium Lipid Metabolism Lipids Adolescent Adult Body Fluids Case-Control Studies Endometriosis Endometrium Female Humans Lipid Metabolism Lipids Young Adult

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Cited by (37)

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