Expression of Protein Markers of Adipogenesis in Endometriotic Lesions

Olga Malysheva, Olga Kopteva, Yu.S. Krylova, А. С. Молотков, Natalia S. Osinovskaya, Natalia Shved, Maria I. Yarmolinskaya, В. С. Баранов
In: Cell and Tissue Biology · 2020 · vol. 14(2) , pp. 129–138 · doi:10.1134/s1990519x20020066 · W3016548229
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that endometriotic lesions and underlying peritoneum express high levels of adipogenesis markers (FABP4, PLA2G2A, ADH1B, C7), suggesting a role for adipogenic stem cells in endometriosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The study examined expression of adipogenesis-associated protein markers—C7, FABP4, ADH1B, and PLA2G2A—in endometriotic lesions and peritoneal tissue by comparing ectopic versus eutopic endometrium, then validating findings using real-time PCR and immunohistochemistry in peritoneal samples from patients with endometriosis and healthy controls. The authors found that high expression of these genes was attributable to endometriotic lesions and peritoneal cells rather than eutopic endometrium, with expression differences reported as roughly 200–300-fold in prior data and confirmed by the performed validation assays. They interpret similarly high expression in endometriotic nodules and adjacent peritoneum as consistent with a common origin, supporting the metaplastic theory, and propose adipogenic stem cells as potentially involved in pathogenesis, while noting the evidence is based on expression rather than direct mechanistic demonstration. This paper is centrally about endometriosis — specifically, it assesses adipogenesis marker genes/proteins (C7, FABP4, ADH1B, PLA2G2A) expressed in endometriotic lesions and surrounding peritoneum.

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Abstract

Endometriosis is a widespread disorder in which a tissue morphologically and physiologically similar to endometrium is observed outside the uterine cavity. Earlier, we identified a number of genes that are overexpressed in ectopic endometrium compared to eutopic endometrium. C7, FABP4, ADH1B, and PLA2G2A were the most expressed genes. The difference in their expression level was 200–300 times higher. In this work, we verified the results using real-time PCR and immunohistochemistry and examined the expression of these genes in the peritoneum of patients with endometriosis and healthy women. We have shown that a high level of expression of these genes is due to endometriotic lesions and peritoneal cells rather than eutopic endometrium. The proteins encoded by these genes (FABP4, PLA2G2A, and ADH1B) are known to be adipogenesis markers. Protein C7 is also involved in the differentiation of adipose stem cells. The equally high level of expression of these genes in endometriosis nodules and underlying peritoneum may point to a common origin of these tissues, which supports the metaplastic theory of the origin of endometriosis. In addition, our data can be interpreted as an indication that adipogenic stem cells may play a role in the pathogenesis of endometriosis. Also, our data can be interpreted as an indication of a possible involvement of adipogenic stem cells in the pathogenesis of endometriosis.

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endometriosis

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