А. С. Молотков

BACKGROUND:External genital endometriosis is a multifactorial estrogen-dependent disease. Local estrogen production due to aromatase activity can play an important role in its pathogenesis, so aromatase inhibitors are considered promising d…

BACKGROUND: Endometriomas are most common during the reproductive years and have an extremely negative impact on ovarian reserve and fertility. In this case, the main method of treatment remains surgery, which inevitably injures healthy ova…

The incidence of adenomyosis in young patients who have not realized their reproductive function is steadily increasing, with the tactics of surgical and drug treatment being an unresolved problem. In clinical practice, special attention is…

To understand a role for anti-Muller hormone (AMH) in the development and course of genital endometriosis, we sought out for and analyzed scientific papers in open electronic sources: PubMed, Scopus, eLibrary. We review a role of AMH in fem…

BACKGROUND: Uterine leiomyoma and endometriosis are the most common gynecological diseases in women of reproductive age. A number of data indicate that there are common elements in the pathogenesis of these hyperproliferative conditions. Th…

The capacity decidualization was examined of cultured cells derived from healthy women and patients with gynecological pathology . The decidualization was induced by combination of estradiol with progesterone and its new analogues. The tech…

OBJECTIVE: The present study was to find a pathogenic evidence for dopamine agonist application in patients with endometriosis associated pain syndrome. PATIENTS AND TECHNIQUE: The study involved 227 patients of reproductive age with histol…

Endometriosis is a widespread disorder in which a tissue morphologically and physiologically similar to endometrium is observed outside the uterine cavity. Earlier, we identified a number of genes that are overexpressed in ectopic endometri…

Hypothesis/aims of study. Endometriosis is one of the most pressing problems of gynecology. Clarifying the expression of the estrogen receptor (ESR1) and the progesterone receptor (PGR) genes and polymorphisms in the aromatase (CYP19A1) gen…

The necessity of finding new drugs for the treatment of endometriosis is stipulated by significant number of recurrences, side effects, and high cost of treatment. Increased activity of aromatase in endometrioid heterotopies is revealed. Th…

Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor path…

In the article a review of the main classifications of endometriosis is presented. Main drawbacks of existing classifications have been revealed. A need for a new classification of the disease, which has to be empirical, evidence-based, con…

Introduction. One of the leading problems of modern reproductive surgery is treatment of adhesive disease, and in turn, prevention of intrauterine adhesions after intrauterine interventions is of particular interest. Purpose: to evaluate t…

Background. There is no clear idea of what factors determine the characteristics of pain in endometriosis. Scientific data on the relationship between morphological and functional features of heterotopic tissue, and the intensity of the pai…

We present a comparative analysis of the allelic polymorphism of the matrix metalloproteinase (MMP) gene family, including MMP3 (rs3025058), MMP7 (rs11568818), MMP9 (rs17576, rs2250889), MMP12 (rs2276109), and MMP13 (rs2252070), in patients…

Three case reports of patients with chronic pelvic pain caused rare pathology described in this article. Diagnostic algorithm, results of examination, laparoscopic findings were shown. These case reports may be interesting for gynecologists…

We present a comparative analysis of the allelic polymorphisms of the matrix metalloproteinase (MMP) gene family, including MMP3 (rs3025058), MMP7 (rs11568818), MMP9 (rs17576, rs2250889), MMP12 (rs2276109), and MMP13 (rs2252070), in patient…

The article represents our experience in evaluation of aromatase activity in endometriotic lesions. We revealed that the most important parameter in evaluating aromatase activity is the area of its expression. Increased activity of this enz…