Features of the morphological structure of endometrial infiltrates in women with chronic pelvic pain syndrome

Background. There is no clear idea of what factors determine the characteristics of pain in endometriosis. Scientific data on the relationship between morphological and functional features of heterotopic tissue, and the intensity of the pain syndrome is extremely small. Purposes and tasks. To determine the features of the morphological structure of endometrial infiltrates in women with chronic pelvic pain syndrome. Materials and methods. We examined 32 patients with infiltrative endometriosis. Pain intensity was determined in accordance with a 10-point visual analog scale (VAS). Preparation of material for histological study was carried out during the execution of the operating laparoscopy. Histological sections stained with hematoxylin and eosin. The study was conducted with increasing ×100. Histological examination was carried out a descriptive and semi-quantitative assessment of glandular-stromal component biopsy, infiltration of inflammatory cells number, as well as the presence of blood vessels (arterioles, venules). Statistical analysis of the material was carried out using the Microsoft Excel 2013 and Stastistica 10.0 for Windows. Results. During the correlation analysis of the relationship between the intensity of pain and the severity of the vascular component revealed a strong correlation (Rs = 0.71, p < 0.05). With the severity of glandular-stromal component biopsy revealed moderate correlation (Rs = 0.49, p 0.05). Conclusions. In severe degree of pain severity predominated infiltrates a lot of glands and stroma expressed vascular component, multiple foci of hemorrhage and severe degree of infiltration of inflammatory cells number. When pain syndrome of moderate severity, as in mild, was found mostly poorly and moderately pronounced glandular-stromal component, and infiltration of inflammatory cells number.