Malignome auf dem Boden einer Endometriose

U. Ulrich, Edit Drienko, V Reichert, A. Wunschel, F. Noack
In: Gynäkologische Endokrinologie · 2016 · vol. 14(1) , pp. 26–30 · doi:10.1007/s10304-015-0043-1 · W2270496803
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis can undergo malignant transformation into various carcinoma types, with PTEN and ARID1A mutations observed, and current research aims to characterize these tumors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews how potentially malignant tumors can arise in tissues affected by endometriosis, noting that malignant transformation may occur via atypia in benign endometriosis. It summarizes histopathologic patterns of endometriosis-associated malignancies—predominantly clear-cell and endometrioid carcinomas—and reports older estimates of malignant transformation risk (~1% overall, ~2.5% for ovarian endometriomas with a reported range of 2–17%), along with molecular findings such as PTEN and ARID1A mutations and loss of heterozygosity. A key limitation explicitly acknowledged by context is reliance on older literature estimates for transformation risk, and the authors describe an ongoing retrospective SEF/AGO study with histopathologic second review in a reference lab to better characterize these tumors. This paper is centrally about endometriosis — it specifically discusses malignancies arising in the setting of endometriosis and related molecular and pathological features.

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last seen: 2026-06-10T17:14:06.276822+00:00
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