Predictive Role of Progesterone Levels for IVF Outcome in Different Phases of Controlled Ovarian Stimulation for Patients With and Without Endometriosis: Expert View

Jovan Bila, Dinara Makhadiyeva, Jelena Dotlić, Jelena Dotlic, Mladen Andjic, Mladen Andjić, Gulzhanat Aimagambetova, Sanja Terzic, Gauri Bapayeva, Antonio Simone Laganà, Antonio Sarría‐Santamera, Antonio Sarria-Santamera, Milan Terzic, Milan Terzić
Reproductive sciences (Thousand Oaks, Calif.) · 2024 · vol. 31(7) , pp. 1819–1827 · doi:10.1007/s43032-024-01490-2 · PMID:38388924 · W4392030310
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This review examined progesterone levels on stimulation, trigger, and aspiration days as IVF outcome predictors, finding trigger day levels combined with oocyte number most powerful, while high baseline progesterone correlated with poor outcomes.

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Abstract

The study aimed to review the role of basal, trigger, and aspiration day progesterone levels (PLs) as predictors of in vitro fertilization (IVF) success for patients with and without endometriosis. A non-systematic review was conducted by searching papers published in English during the period of 1990-2023 in MEDLINE and PubMed, Embase, The Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register), and Web of Science. The most widely used IVF predictor success was the trigger day progesterone serum level. Many studies utilize the threshold level of 1.5-2.0 ng/ml. However, the predictive power of only progesterone level failed to show high sensitivity and specificity. Contrary, progesterone level on the trigger day combined with the number of mature retrieved oocytes had the highest predictive power. High baseline progesterone level was associated with poor IVF outcomes. Research on progesterone and IVF success in patients with endometriosis is limited but indicates that endometriosis patients seem to benefit from higher progesterone concentrations (≥ 37.1 ng/ml) in IVF cycles. Currently, there is limited data for a definitive insight into the mportance of progesterone in the estimation of IVF success. Nonetheless, this summarized evidence could serve as up-to-date guidance for the role of progesterone in the prediction of IVF outcomes, both in patients with and without endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (68)

Cited by (1)

SciLite annotations

chemicals 8
progesterone progesterone progesterone progesterone progesterone progesterone progesterone progesterone

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