JeHoon Lee

ORCID: 0000-0002-2709-6941 · 26 papers in corpus · active 2007-2025

Study types

  • article 23
  • other 2
  • letter 1

Condition tags

  • endometriosis 18
  • mesh:D004715 10
  • infertility 6
  • chronic_pelvic_pain 3
  • mesh:D017699 1
letter 2025
New perspectives about the article “Dual inhibition of AKT and ERK1/2 pathways restores the expression of progesterone Receptor-B in endometriotic lesions through epigenetic mechanisms"
·doi:10.1016/j.mce.2025.112496
other 2024
Dual inhibition of AKT and ERK1/2 pathways restores the expression of progesterone Receptor-B in endometriotic lesions through epigenetic mechanisms
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2024.112290

Endometriosis is an estrogen-dependent and progesterone-resistant gynecological inflammatory disease of reproductive-age women. Progesterone resistance, loss of progesterone receptor -B (PR-B) in the stromal cells of the endometrium, is one…

article 2022
Effects of selective inhibition of prostaglandin E2 receptors EP2 and EP4 on the miRNA profile in endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2022.111728
article 2021
Effects of dual inhibition of AKT and ERK1/2 pathways on endometrial pro-inflammatory, hormonal, and epigenetic microenvironment in endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2021.111446
article 2016
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms

Short Title: PGE2 signaling in adhesion of human endometriotic cells Summary Sentence: Selective inhibition of PGE2 receptors EP2 and EP4 disassembled integrin linkage mechanisms and disturbed integrin outside-in and inside-out signaling pa…

article 2016
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells

Endometriosis is a chronic gynecological disease of reproduc-tive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracel…

article 2015
Molecular and preclinical basis to inhibit PGE 2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1507931112

Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant, inflammatory gynecological disease of reproductive age women. Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and subfertility or …

article 2015
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2015.03.023
article 2013
PPARγ Activation Inhibits Growth and Survival of Human Endometriotic Cells by Suppressing Estrogen Biosynthesis and PGE2 Signaling.
Endocrinology ·doi:10.1210/en.2013-1168

Endometriosis is a chronic inflammatory disease of reproductive age women leading to chronic pelvic pain and infertility. Current antiestrogen therapies are temporizing measures, and endometriosis often recurs. Potential nonestrogenic or no…

article 2013
Unraveling the moleculr interactions between PGE2 signaling and pain pathways in endometriosis
·doi:10.1016/j.fertnstert.2013.07.1701
article 2012
Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells Through Deregulated Integrin-Mediated Mechanisms.
·doi:10.1093/biolreprod/87.s1.545

BACKGROUND: Endometriosis is a chronic inflammatory disease of reproductive-age women. Adhesion of endometriotic epithelial and stromal cells to peritoneum is mediated through integrin and extracellular matrix (ECM) protein interactions. In…

article 2012
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells Through Suppression of Integrin-Mediated Mechanisms1
Biology of reproduction ·doi:10.1095/biolreprod.112.100883

Endometriosis is a chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracell…

article 2012
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Growth of Experimental Endometriosis in Nude Mice Evaluated by Real-time Noninvasive Imaging and Fluorescence Microscopy.
·doi:10.1093/biolreprod/87.s1.550

Endometriosis is a highly prevalent estrogen-dependent gynecological inflammatory disease of reproductive-age women characterized by the presence of functional endometrial cells outside the uterus commonly leading to inflammation, pain and …

article 2010
Expression and Regulation of Prostaglandin Biosynthetic Enzymes Cox-2 and Pges-1 and Receptors EP1, EP2, EP3, and EP4 in Endometriosis in the Nonhuman Primate.
·doi:10.1093/biolreprod/83.s1.168

Endometriosis is a debilitating disease where endometrium-like tissue forms lesions outside the uterus that result in chronic pelvic pain and infertility in 10-20% of women of reproductive age. Endometriosis is an estrogen-dependent disease…

other 2010
Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.01.038

OBJECTIVE: To determine interactions between prostaglandin (PG) E(2) signaling and proliferation of endometriotic cells to increase our knowledge about PGE(2) signaling in the pathogenesis of endometriosis in humans. DESIGN: Immortalized h…

article 2010
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion, migration, and invasion of human endometriotic cells
·doi:10.1016/j.fertnstert.2010.07.783
article 2010
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2010.11.022
article 2009
PPAR-gamma ligand activation decreases p450 aromatase gene expression in human endometriotic epithelial and stromal cells in vitro
·doi:10.1016/j.fertnstert.2009.07.046
article 2009
Prostaglandin E2 Regulates Survival of Human Endometriotic Epithelial and Stromal Cells by Integrating EGFR, NFkB, and Wnt Signaling Pathways Through EP2 and EP4 Receptors.
·doi:10.1093/biolreprod/81.s1.150

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that results in chronic pelvic pain and i…

article 2009
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2009-0017

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

article 2009
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms
·doi:10.1210/jcem.94.7.9993

Endometriosis is a benign chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

article 2009
Selective inhibition of prostaglandin E2 signaling inhibits migration and invasion of human endometriotic epithelial and stromal cells through multiple mechanisms
·doi:10.1016/j.fertnstert.2009.07.043
article 2007
Cyclooxygenase-2 Regulates Survival, Migration, and Invasion of Human Endometriotic Cells through Multiple Mechanisms
Endocrinology ·doi:10.1210/en.2007-1168

Endometriosis is a debilitating disease characterized by the presence of functional endometrial glandular epithelium and stroma outside the uterine cavity that affects up to 20% of women of child-bearing age. Cyclooxygenase-2 (COX-2), a rat…

article 2007
Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1358
article 2007
GENE EXPRESSION PROFILES IN HUMAN IMMORTALIZED ENDOMETRIOTIC EPITHELIAL AND STROMAL CELLS: CYCLOOXYGENASE-2 REGULATES CELL PROLIFERATION, MIGRATION AND INVASION
·doi:10.1093/biolreprod/77.s1.158

Endometriosis is a debilitating disease affects up to 20% of reproductive age women characterized by the presence of functional endometrial glandular epithelium and stroma out side the uterine cavity. The pathophysiology of endometriosis re…