Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms

Short Title: PGE2 signaling in adhesion of human endometriotic cells Summary Sentence: Selective inhibition of PGE2 receptors EP2 and EP4 disassembled integrin linkage mechanisms and disturbed integrin outside-in and inside-out signaling pathways and thereby inhibited adhesion of human endometriotic epithelial and stromal cells to extracellular matrix proteins in an epithelial-stromal cell and substrate specific manner.