Robert C. Burghardt

ORCID: 0000-0003-1021-8444 · 9 papers in corpus
2023
Hexavalent Chromium Disrupts Oocyte Development in Rats by Elevating Oxidative Stress, DNA Double-Strand Breaks, Microtubule Disruption, and Aberrant Segregation of Chromosomes.
International journal of molecular sciences ·doi:10.3390/ijms241210003

Environmental and occupational exposure to hexavalent chromium, Cr(VI), causes female reproductive failures and infertility. Cr(VI) is used in more than 50 industries and is a group A carcinogen, mutagenic and teratogenic, and a male and fe…

article 2016
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms

Short Title: PGE2 signaling in adhesion of human endometriotic cells Summary Sentence: Selective inhibition of PGE2 receptors EP2 and EP4 disassembled integrin linkage mechanisms and disturbed integrin outside-in and inside-out signaling pa…

article 2016
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells

Endometriosis is a chronic gynecological disease of reproduc-tive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracel…

article 2015
Molecular and preclinical basis to inhibit PGE 2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1507931112

Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant, inflammatory gynecological disease of reproductive age women. Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and subfertility or …

article 2012
Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells Through Deregulated Integrin-Mediated Mechanisms.
·doi:10.1093/biolreprod/87.s1.545

BACKGROUND: Endometriosis is a chronic inflammatory disease of reproductive-age women. Adhesion of endometriotic epithelial and stromal cells to peritoneum is mediated through integrin and extracellular matrix (ECM) protein interactions. In…

article 2012
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells Through Suppression of Integrin-Mediated Mechanisms1
Biology of reproduction ·doi:10.1095/biolreprod.112.100883

Endometriosis is a chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracell…

article 2012
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Growth of Experimental Endometriosis in Nude Mice Evaluated by Real-time Noninvasive Imaging and Fluorescence Microscopy.
·doi:10.1093/biolreprod/87.s1.550

Endometriosis is a highly prevalent estrogen-dependent gynecological inflammatory disease of reproductive-age women characterized by the presence of functional endometrial cells outside the uterus commonly leading to inflammation, pain and …

2010
Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.
Molecular human reproduction ·doi:10.1093/molehr/gap095

Uterine receptivity to implantation varies among species, and involves changes in expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal and superficial glandular epithelia, modification of phenotype of …

article 2008
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.06.050

ObjectiveTo determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice.DesignProspective experimental study. Human immortalized endometriosis…