Src as a novel therapeutic target for endometriosis

Kate Lawrenson, Nathan Lee, Lee N, Torres HA, Hugo A. M. Torres, Lee JM, Janet M. Lee, Brueggmann D, Doerthe Brueggmann, Priya Rao, P Nagesh Rao, Rao PN, Houtan Noushmehr, Noushmehr H, Gayther SA, Simon A. Gayther
Gynecologic Oncology · 2014 · vol. 135(1) , pp. 100–107 · doi:10.1016/j.ygyno.2014.06.016 · PMID:24972189 · W2005388734
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the role of Src in endometriosis and identified it as a potential therapeutic target.

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Abstract

BackgroundEndometriosis is a common condition that is associated with an increased risk of developing ovarian carcinoma. Improved in vitro models of this disease are needed to better understand how endometriosis, a benign disease, can undergo neoplastic transformation, and for the development of novel treatment strategies to prevent this progression.MethodsWe describe the generation and in vitro characterization of novel TERT immortalized ovarian endometriosis epithelial cell lines (EEC16-TERT).ResultsExpression of TERT alone was sufficient to immortalize endometriosis epithelial cells. TERT immortalization induces an epithelial-to-mesenchymal transition and perturbation in the expression of genes involved in the development of ovarian cancer. EEC16-TERT was non-tumorigenic when xenografted into immunocompromised mice but grew in anchorage-independent growth assays in an epidermal growth factor and hydrocortisone dependent manner. Colony formation in agar was abolished by inhibition of Src, and the Src pathway was found to be activated in human endometriosis lesions.ConclusionsThis new in vitro model system mimics endometriosis and the early stages of neoplastic transformation in the development of endometriosis associated ovarian cancer. We demonstrate the potential clinical relevance of this model by identifying Src activation as a novel pathway in endometriosis that could be targeted therapeutically, perhaps as a novel strategy to manage endometriosis clinically, or to prevent the development of endometriosis-associated ovarian cancer.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometriosis Endometriosis Genes, src Ovarian Diseases Ovarian Diseases Ovarian Neoplasms Ovarian Neoplasms Animals Cells, Cultured Endometriosis Endometriosis Epithelial Cells Female Genes, src Genes, src Humans Mice Ovarian Diseases Ovarian Diseases

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