Pregnancy outcomes in women with adenomyosis, undergoing artificial endometrial preparation with and without gonadotropin-releasing hormone agonist pretreatment in frozen embryo transfer cycles: An RCT

Marzieh Eslami Moayed, Ashraf Moini, Ladan Kashani, Maryam Farid Mojtahedi, Tawoos Rezaee, Hamed Tabasizadeh, Khadıje Maajani, Khadije Maajani, Nazila Yamini
International journal of reproductive biomedicine · 2023 · vol. 21(6) , pp. 481–490 · doi:10.18502/ijrm.v21i6.13635 · PMID:37560066 · W4385199340
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Artificial endometrial preparation with estrogen and progestin for frozen embryo transfer cycles demonstrated comparable pregnancy and live birth rates to GnRH agonist pretreatment in women with adenomyosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This randomized trial compared pregnancy outcomes in women diagnosed with adenomyosis undergoing frozen embryo transfer with artificial endometrial preparation, testing regimens with versus without gonadotropin-releasing hormone agonist pretreatment. The study’s key finding was the effect (or lack of difference) of adding GnRH agonist pretreatment on subsequent pregnancy outcomes in this adenomyosis population within the artificial preparation framework. The paper’s main limitation, as typically stated in RCTs like this, is that results are constrained by the trial’s sample size and study setting, which can affect generalizability. This paper is centrally about adenomyosis—evaluating how GnRH agonist pretreatment influences pregnancy outcomes during frozen embryo transfer with artificial endometrial preparation.

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Abstract

Background: Selecting a suitable and preferable method for endometrial preparation in frozen embryo transfer (FET) cycles for women with adenomyosis is still challenging in infertility treatment. Objective: To compare 2 artificial endometrial preparation regimens with and without gonadotropin-releasing hormone agonist (GnRHa) pretreatment in women with adenomyosis undergoing FET cycles. Materials and Methods: This randomized clinical trial study was conducted on 140 adenomyosis cases who underwent FET cycles at Arash Women's hospital, Tehran, Iran from May 2020 to March 2021. Participants were randomly allocated into hormonal replacement therapy (HRT) and HRT+GnRHa pretreatment groups (n = 70/each). Endometrial preparation with 2-6 mg daily estradiol was started in the HRT+GnRHa group, taking after down-regulation with the GnRHa. Within the HRT group, the same dose of estradiol was commenced within the early follicular stage. The main (chemical and clinical pregnancy rates) and auxiliary results (twin pregnancy, miscarriage, and live birth rates) were compared between groups. Results: The demographic characteristics and severity of adenomyosis, endometrial thickness, and pattern at starting progesterone administration were similar in the 2 groups, and triple-line endometrium was found to be the dominant pattern in both groups (p = 0.65). No significant differences were observed in chemical, clinical, and twin pregnancy rates as well as miscarriage and live birth rates between groups (p = 0.71, p = 0.81, p = 0.11, and p = 0.84, respectively). However, the total estrogen dose and duration of estrogen consumption were significantly higher in the pretreatment group (p = 0.001, and p = 0.003). Conclusion: These results indicated that the hormonal endometrial preparation with estrogen and progestin for FET cycles is as efficacious as a protocol involving preceding pituitary suppression with a GnRHa. Further large randomized clinical studies are required to confirm these findings.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 19 July 2023 Authors Marzieh Eslami Moayed | Ashraf Moini | Ladan Kashani | Maryam Farid Mojtahedi | Tawoos Rezaee | Hamed Tabasizadeh | Khadije Maajani | Nazila Yamini The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v21i6.13635', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/13635', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://ijrm.ir/article-1-2668-en.html', 'tld': 'ijrm.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/13635', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '19 July 2023', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Pregnancy outcomes in women with adenomyosis, undergoing artificial endometrial preparation with and without gonadotropin-releasing hormone agonist pretreatment in frozen embryo transfer cycles: An RCT', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v21i6.13635', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Marzieh Eslami Moayed | Ashraf Moini | Ladan Kashani | Maryam Farid Mojtahedi | Tawoos Rezaee | Hamed Tabasizadeh | Khadije Maajani | Nazila Yamini', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v21i6.13635 JSON XML

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