Refining the Adenomyosis Molecular Fingerprint

Maria Rosa Maduro
In: Reproductive Sciences · 2017 · vol. 24(3) , pp. 337–338 · doi:10.1177/1933719116688839 · W3152116175
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This review compiles findings from multiple studies on adenomyosis, highlighting its complex molecular fingerprint, including transcriptome abnormalities, cytokine profiles, inflammation, and nerve fiber interactions.

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This editorial piece introduces a special issue of Reproductive Sciences dedicated to advancing the understanding of adenomyosis through molecular profiling. It highlights recent studies that utilize transcriptomic and proteomic analyses to identify distinct genetic and inflammatory signatures within the eutopic endometrium and myometrium of affected women. The author emphasizes how these refined molecular fingerprints help clarify the pathogenesis of the disease, distinguishing it from endometriosis and other uterine disorders. This paper is centrally about adenomyosis — specifically focusing on the identification of unique molecular markers to improve diagnosis and treatment strategies for the condition.

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References Maheshwari A, Gurunath S, Fatima F, Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update. 2012;18(4):374–392. Reis FM, Petraglia F, Taylor RN. Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update. 2013;19(4):406–418. McKinnon BD, Bertschi D, Bersinger NA, Mueller MD. Inflammation and nerve fiber interaction in endometriotic pain. Trends Endocrinol Metab. 2015;26(1):1–10. Herndon CN, Aghajanova L, Balayan S, et al. Global Transcriptome abnormalities of the eutopic endometrium from women with adenomyosis. Reprod Sci. 2016;23(10):1289–1303. Zhihong N, Yun F, Pinggui Z, Sulian Z, Zhang A. Cytokine profiling in the eutopic endometrium of adenomyosis during the implantation window after ovarian stimulation. Reprod Sci. 2016;23(1):124–133. Lazzeri L, Di Giovanni A, Exacoustos C, et al. Preoperative and postoperative clinical and transvaginal ultrasound findings of adenomyosis in patients with deep infiltrating endometriosis. Reprod Sci. 2014;21(8):1027–1033. Zhu B, Chen Y, Zhang H, Liu X, Guo SW. Resveratrol reduces myometrial infiltration, uterine hyperactivity, and stress levels and alleviates generalized hyperalgesia in mice with induced adenomyosis. Reprod Sci. 2015;22(11):1336–1349. Streuli I, Santulli P, Chouzenoux S, Chapron C, Batteux F. Activation of the MAPK/ERK cell-signaling pathway in uterine smooth muscle cells of women with adenomyosis. Reprod Sci. 2015;22(12):1549–1560. Li Y, Zou S, Xia X, Zhang S. Human adenomyosis endometrium stromal cells secreting more nerve growth factor: impact and effect. Reprod Sci. 2015;22(9):1073–1082. Carrarelli P, Yen CF, Funghi L, et al. Expression of inflammatory and neurogenic mediators in adenomyosis: a pathogenetic role. Reprod Sci. 2017;24(3):369–375. Rights and permissions About this article Cite this article Maduro, M.R. Refining the Adenomyosis Molecular Fingerprint. Reprod. Sci. 24, 337–338 (2017). https://doi.org/10.1177/1933719116688839 Published: Issue date: DOI: https://doi.org/10.1177/1933719116688839

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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