Are lower levels of apoptosis and autophagy behind adenomyotic lesion survival?

Marie d'Argent, Christina Anna Stratopoulou, Sophie Cussac, Alessandra Camboni, Pascale Jadoul, Jacques Donnez, Marie-Madeleine Dolmans, Marie‐Madeleine Dolmans
Reproductive biomedicine online · 2023 · vol. 47(3) , pp. 103248 · doi:10.1016/j.rbmo.2023.06.003 · PMID:37451972 · W4380742892
article OA: green CC0 ⤵ 7 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Adenomyotic lesions exhibit reduced apoptosis and autophagy, alongside increased MMP9 expression and progesterone resistance, suggesting these factors contribute to disease pathogenesis and survival.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Full text 2,849 characters · extracted from oa-html · click to expand
Are lower levels of apoptosis and autophagy behind adenomyotic lesion survival? (2023) Reproductive BioMedicine Online — Vol. 47, n° 3, p. 103248 [1-9] (2023) (2023) Reproductive BioMedicine Online — Vol. 47, n° 3, p. 103248 [1-9] (2023) Open Access - Adobe PDF - 2.31 MB - Authors - Author d'Argent, Marie UCLouvain - Author Stratopoulou, Christina Anna UCLouvain - Author Cussac, Sophie UCLouvain - Author Camboni, Alessandra UCLouvain - Author Jadoul, Pascale UCLouvain - Author - Abstract - (en) RESEARCH QUESTION: How are markers of cell death, invasiveness and progesterone signalling expressed in endometrium and ectopic lesions from adenomyosis patients? DESIGN: Formalin-fixed paraffin-embedded tissue was collected from 15 control and 15 adenomyosis participants . To assess cell survival capacity, caspase 3 and microtubule-associated proteins 1A/1B light chain 3B (LC3B) were immunolabelled as markers of apoptosis and autophagy respectively. Matrix metalloproteinase 9 (MMP9) expression served as a marker of extracellular matrix degradation and invasion activity. Progesterone receptors were immunostained to detect evidence of progesterone resistance. RESULTS: Caspase 3 expression was significantly lower in the stromal (P = 0.0013) and epithelial (P = 0.0157) compartments of adenomyotic lesions than in healthy endometrial tissue. In the stroma, caspase 3 expression was significantly weaker in lesions than in corresponding eutopic endometrium (P = 0.0006). LC3B immunostaining was significantly decreased in adenomyotic stroma compared with corresponding eutopic endometrium (P = 0.0349). A significantly higher expression of MMP9 was detected in eutopic stroma from adenomyosis patients than in healthy tissue (P = 0.0295). Progesterone receptor immunostaining was found to be significantly weaker in the stroma of endometrium and ectopic lesions from adenomyosis patients than disease-free women (P = 0.0001; P = 0.0021). CONCLUSIONS: Adenomyotic lesions show lower levels of apoptosis and autophagy, suggesting that aberrant cell survival may be involved in disease pathogenesis. MMP9 appears to contribute to endometrial invasiveness in adenomyosis, as its expression is more pronounced in endometrium from these women than women without the disease. Evidence of progesterone resistance can be found in endometrium and ectopic lesions from adenomyosis patients, and may drive disease development and account for the failure of certain patients to respond to progestogens. - Affiliations - APA - Chicago - FWB d’Argent, M., Stratopoulou, C. A., Cussac, S., Camboni, A., Jadoul, P., Donnez, J., & Dolmans, M.-M. (2023). Are lower levels of apoptosis and autophagy behind adenomyotic lesion survival? Reproductive BioMedicine Online, 47(3), 103248 [1-9]. https://doi.org/10.1016/j.rbmo.2023.06.003 (Original work published 2023)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

mesh:D004715

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (47)

Cited by (7)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-29T00:33:31.442335+00:00
License: CC0 · commercial use OK