What if deep endometriotic nodules and uterine adenomyosis were actually two forms of the same disease?
This paper proposes that deep endometriotic nodules and uterine adenomyosis might be two manifestations of a single disease, noting their overlapping symptoms and similar histologic patterns.
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This short perspective paper compares deep rectovaginal endometriotic nodules with uterine adenomyosis, focusing on clinical symptom overlap (e.g., severe dysmenorrhea) and histologic similarities. It notes that deep endometriotic nodules were previously described as “adenomyomas” (including smooth muscle hyperplasia with active glandular epithelium and scanty stroma) and argues that the histologic patterns of deep endometriosis and uterine adenomyosis appear very similar. The paper’s main limitation is its narrative, hypothesis-driven format rather than presenting new empirical data or a systematic analysis. This paper is centrally about endometriosis and adenomyosis—proposing that deep endometriotic nodules and uterine adenomyosis may represent two forms of the same disease.
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References (5)
- Pathogenesis of uterine adenomyosis: invagination or metaplasia? via openalex
- Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes via openalex
- Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis via openalex
- W327937967 via openalex
- W1754070801 via openalex
Cited by (36)
- Mediocentral Compartment: Uterus: External Adenomyosis 2025
- Phenotypic heterogeneity in adenomyosis: internal and external subtypes 2025
- Drug development for adenomyosis based on pathophysiology 2025
- Endometriosis and Adenomyosis 2024
- Overview of crosstalk between stromal and epithelial cells in the pathogenesis of adenomyosis and shared features with deep endometriotic nodules 2024
- Society of Endometriosis and Uterine Disorders forum: adenomyosis today, Paris, France, December 12, 2023 2024
- “Call me by my true names”. The utopian search for endometriosis and adenomyosis terminology devoid of ambiguous pathogenic meaning: Just an illusion? 2023
- Are lower levels of apoptosis and autophagy behind adenomyotic lesion survival? 2023
- Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? 2023
- Characterising the immune cell phenotype of ectopic adenomyosis lesions compared with eutopic endometrium: A systematic review 2023
- Endometriosis and adenomyosis: Similarities and differences 2023
- Differences clinical characteristics and factors in intrinsic and extrinsic adenomyosis 2023
- Extrauterine adenomyomas managed by laparoscopic excision: Three case reports with different theories of origin 2023
- Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility 2022
- Pathogenesis of Endometriosis: Theories of the Cells of Origin and Methods of Dissemination 2022
- MRI of Adenomyosis: Where Are We Today? 2022
- Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology 2022
- MRI of Adenomyosis: Where Are We Today? 2022
- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- Spatiotemporal expression pattern of Progesterone Receptor Component (PGRMC) 1 in endometrium from patients with or without endometriosis or adenomyosis 2022
- Uterine Adenomyosis Treated by Linzagolix, an Oral Gonadotropin-Releasing Hormone Receptor Antagonist: A Pilot Study with a New ’Hit Hard First and then Maintain’ Regimen of Administration 2021
- Identifying Common Pathogenic Features in Deep Endometriotic Nodules and Uterine Adenomyosis 2021
- Minimally invasive adenomyomectomy via a laparoscopic-assisted approach compared to a laparoscopic or laparotomic approach 2021
- Ectopic Endometrium: The Pathologist’s Perspective 2021
- Laparoscopic “Shaving” for Infiltrative External Adenomyosis of Bowel Muscularis and Concomitant Deep Infiltrating Endometriosis 2021
- Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review 2021
- Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists 2021
- Exploring the challenges for a new classification of adenomyosis 2020
- Efficacy of the levonorgestrel-releasing intrauterine device is associated with different subtypes of adenomyosis: a retrospective study 2020
- Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis 2020
- The role of imaging as a guide to the surgical treatment of endometriosis 2020
- Androgens, oestrogens and endometrium: a fine balance between perfection and pathology 2020
- Pathology and Pathogenesis of Adenomyosis 2020
- Epidemiology of Adenomyosis 2020
- Deep endometriosis: The place of laparoscopic shaving 2020
- A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis 2019
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