What if deep endometriotic nodules and uterine adenomyosis were actually two forms of the same disease?

Jacques Donnez, Donnez J, Dolmans MM, Marie-Madeleine Dolmans, Marie‐Madeleine Dolmans, Fellah L, Latifa Fellah
Fertility and sterility · 2019 · vol. 111(3) , pp. 454–456 · doi:10.1016/j.fertnstert.2018.12.018 · PMID:30722943 · W2911936721
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⚙ AI-generated summary by claude@2026-07+body, 2026-07-08 ⓘ

This paper proposes that deep endometriotic nodules and uterine adenomyosis are two manifestations of the same disease, citing similar histologic patterns and overlapping symptoms like severe dysmenorrhea.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This short perspective paper compares deep rectovaginal endometriotic nodules with uterine adenomyosis, focusing on clinical symptom overlap (e.g., severe dysmenorrhea) and histologic similarities. It notes that deep endometriotic nodules were previously described as “adenomyomas” (including smooth muscle hyperplasia with active glandular epithelium and scanty stroma) and argues that the histologic patterns of deep endometriosis and uterine adenomyosis appear very similar. The paper’s main limitation is its narrative, hypothesis-driven format rather than presenting new empirical data or a systematic analysis. This paper is centrally about endometriosis and adenomyosis—proposing that deep endometriotic nodules and uterine adenomyosis may represent two forms of the same disease.

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What if deep endometriotic nodules and uterine adenomyosis were actually two forms of the same disease? (2019) Fertility and sterility — Vol. 111, n° 3, p. 454-456 (2019) (2019) Fertility and sterility — Vol. 111, n° 3, p. 454-456 (2019) Open Access - Adobe PDF - 340.96 KB - Authors - Author Donnez, Jacques - Author - Author Fellah, Latifa UCLouvain - Abstract - (en) Some symptoms of endometriosis, such as severe dysmenorrhea, overlap with those of uterine adenomyosis, a disease characterized by growth of endometrium into the myometrium. From a histologic point of view, deep rectovaginal endometriotic nodules were described by Donnez et al. (1) back in 1996 as “adenomyomas,” consisting of smooth muscle hyperplasia with active glandular epithelium and scanty stroma. In fact, the histologic patterns of deep endometriosis and uterine adenomyosis appear to be very similar. [...] - Affiliations - APA - Chicago - FWB Donnez, J., Dolmans, M.-M., & Fellah, L. (2019). What if deep endometriotic nodules and uterine adenomyosis were actually two forms of the same disease? Fertility and sterility, 111(3), 454-456. https://doi.org/10.1016/j.fertnstert.2018.12.018 (Original work published 2019)

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Endometrium Endometrium Endometrium Myometrium Myometrium Myometrium Terminology as Topic Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adult Endometriosis Endometriosis Endometriosis Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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