Differences clinical characteristics and factors in intrinsic and extrinsic adenomyosis

Yan Liang, W. Shi, Feng Sun, Minjiao Zhu, Yuan Liu, Jian Zhang
In: Research Square · 2023 · doi:10.21203/rs.3.rs-2752816/v1 · W4367671473
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This study compared intrinsic and extrinsic adenomyosis, finding intrinsic AM associated with higher gravidity, parity, abortions, and curettage, while extrinsic AM was linked to earlier menarche, ovarian endometrioma, deep infiltrating endometriosis, and more severe dysmenorrhea.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This retrospective observational preprint compared clinical characteristics, potential associated factors, and perioperative/postoperative outcomes in premenopausal women with MRI-diagnosed intrinsic (n=77) versus extrinsic (n=54) adenomyosis who underwent hysterectomy between 2019 and 2022. Across groups, gravidity, parity, number of abortions, and endometrial curettage were higher and education level was lower in the intrinsic group, while extrinsic adenomyosis had earlier menarche and was more frequently associated with ovarian endometrioma and deep infiltrating endometriosis; clinically, dysmenorrhea was more severe in extrinsic adenomyosis and menstrual volume was heavier in intrinsic adenomyosis. Extrinsic cases also had longer surgery duration, greater bleeding, higher hospitalization cost, and more postoperative medical therapy, and multivariate analysis linked education level, gravidity, and number of endometrial curettage with intrinsic adenomyosis while ovarian endometrioma and deep infiltrating endometriosis were closely related to extrinsic adenomyosis. Limitations include the preprint status (not peer reviewed) and the retrospective, single-hospital hysterectomy cohort. Relevance to endometriosis: the paper explicitly links extrinsic adenomyosis with ovarian endometrioma and deep infiltrating endometriosis, using r-AFS staging of endometriosis and comparing endometriosis coexistence between subtypes.

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adenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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