Pathogenesis of Endometriosis: Theories of the Cells of Origin and Methods of Dissemination

Dan C. Martin
In: Endometriosis and Adenomyosis · 2022 · pp. 29–42 · doi:10.1007/978-3-030-97236-3_3 · W4285277978
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Theories of endometriosis require a cell of origin, dissemination method, stimulation, and growth mechanisms, with research focused on early events to prevent disease progression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This chapter discusses theories underpinning endometriosis pathogenesis, focusing on the needed “cell of origin,” mechanisms of dissemination or in situ development, biological stimulation that transitions to endometriosis, and processes that enable growth, while noting that inactivation and clearance could limit progression. It argues that research should prioritize early developmental events to prevent later fibrosis and that achieving early diagnosis may require validated medical or surgical protocols. The main caveat is that theories can create false narratives and should not be used to guide treatment, warning about effects such as the “tomato effect” and “medical reversal.” Relevance to endometriosis: the paper is explicitly about endometriosis theories of cellular origin and dissemination, while also briefly juxtaposing endometriosis with uterine adenomyosis as potentially related entities via cited discussions of shared disease concepts.

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endometriosis

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License: CC0 · commercial use OK