Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases

Batt Re, Ronald E. Batt, John Yeh, Yeh J
Reproductive sciences (Thousand Oaks, Calif.) · 2013 · vol. 20(9) , pp. 1030–1037 · doi:10.1177/1933719112472736 · PMID:23314961 · W1998231478
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This study presents evidence supporting the theory of müllerianosis, proposing that misplaced embryonic müllerian tissue causes four developmental diseases: adenomyosis, endometriosis, endosalpingiosis, and endocervicosis.

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The paper presents the theory of “müllerianosis,” proposing that embryonic müllerian tissue misplaced during organogenesis leads to four benign developmental müllerian diseases: developmental adenomyosis, developmental endometriosis, endosalpingiosis, and endocervicosis. The authors summarize evidence from human fetal tissue to support developmental adenomyosis, developmental endometriosis, and developmental endocervicosis, and they describe circumstantial support for all four conditions in female infants, children, adolescents, and adults. A key claim is that this framework helps explain rare müllerian lesions that are not accounted for by classical and modern theories, with the stated caveat that evidence is direct for only some diseases while others rely on circumstantial findings. This paper is centrally about endometriosis — it explicitly proposes developmental endometriosis as a müllerianosis outcome stemming from misplaced embryonic tissue, while also addressing developmental adenomyosis within the same unifying model.

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Abstract

The theory of müllerianosis predicts that embryonic müllerian tissue, misplaced during organogenesis, results in the formation of 4 benign müllerian diseases-developmental adenomyosis, endometriosis, endosalpingiosis, and endocervicosis-(developmental müllerian diseases) that will be identified in human female fetuses, infants, children, adolescents, and adults. Direct evidence is presented to support the existence of developmental adenomyosis, developmental endometriosis, and developmental endocervicosis in human female fetuses along with strong circumstantial evidence supporting the existence of all 4 developmental müllerian diseases in human female infants, children, adolescents, and adults. This evidence throws light upon the pathogenesis of rare müllerian lesions whose pathogenesis remains inexplicable by classical and modern theories. Furthermore, this research has scientific and clinical relevance: scientific relevance because it opens up a new field of comparative research-the 4 developmental müllerian diseases complement the 4 acquired müllerian diseases; clinical relevance because it identifies rare müllerian diseases curable by complete surgical excision.
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Abstract

The theory of müllerianosis predicts that embryonic müllerian tissue, misplaced during organogenesis, results in the formation of 4 benign müllerian diseases—developmental adenomyosis, endometriosis, endosalpingiosis, and endocervicosis—(developmental müllerian diseases) that will be identified in human female fetuses, infants, children, adolescents, and adults. Direct evidence is presented to support the existence of developmental adenomyosis, developmental endometriosis, and developmental endocervicosis in human female fetuses along with strong circumstantial evidence supporting the existence of all 4 developmental müllerian diseases in human female infants, children, adolescents, and adults. This evidence throws light upon the pathogenesis of rare müllerian lesions whose pathogenesis remains inexplicable by classical and modern theories. Furthermore, this research has scientific and clinical relevance: scientific relevance because it opens up a new field of comparative research—the 4 developmental müllerian diseases complement the 4 acquired müllerian diseases; clinical relevance because it identifies rare müllerian diseases curable by complete surgical excision. Similar content being viewed by others

References

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Sci. 20, 1030–1037 (2013). https://doi.org/10.1177/1933719112472736 Published: Issue date: DOI: https://doi.org/10.1177/1933719112472736

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endometriosis

MeSH descriptors

Adenomyosis Choristoma Endometriosis Fallopian Tube Diseases Mullerian Ducts Adenomyosis Adolescent Adult Child Child, Preschool Choristoma Endometriosis Fallopian Tube Diseases Female Humans Infant Infant, Newborn Organogenesis Young Adult

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