In Utero and Early-Life

Information on the development of ectopic endometrial foci during fetal life be deduced from the embryogenesis of the reproductive tract. It is possible that fragments of the Müllerian duct epithelium become displaced to adjacent sites, giving rise to ectopic foci. Congenital endometriosis also remains a possibility. The reported incidence of endometriosis in teenagers with genital tract anomalies varies between 11% and 40%. The incidence appears to be higher in anomalies associated with genital tract outflow obstruction. There is still considerable uncertainty about whether mechanisms such as coelomic metaplasia, embryonic Müllerian rests, or persistence of other forms of embryonic endometriosis are relevant to endometriosis. Mesenchymal stem cells may be the principal source of endometriosis outside the peritoneal cavity. It is possible that progenitor cells play a role also in the pathophysiology of premenarcheal and adolescent endometriosis, since they may originate and implant into the peritoneum as a consequence of retrograde neonatal uterine bleeding. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Kalu E, McAuley W, Richardson R. Teenagers, adolescents, endometriosis and recurrence: a retrospective analysis of recurrence following primary operative laparoscopy. Gynecol Surg. 2008;5:209–12. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Habiba, M., Benagiano, G. (2022). In Utero and Early-Life. In: Oral, E. (eds) Endometriosis and Adenomyosis. Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_11 Download citation DOI: https://doi.org/10.1007/978-3-030-97236-3_11 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-97235-6 Online ISBN: 978-3-030-97236-3 eBook Packages: MedicineMedicine (R0)