{"paper_id":"5f5b7f1a-6150-4032-a189-595f8c06bd83","body_text":"Abstract\nInformation on the development of ectopic endometrial foci during fetal life be deduced from the embryogenesis of the reproductive tract. It is possible that fragments of the Müllerian duct epithelium become displaced to adjacent sites, giving rise to ectopic foci. Congenital endometriosis also remains a possibility. The reported incidence of endometriosis in teenagers with genital tract anomalies varies between 11% and 40%. The incidence appears to be higher in anomalies associated with genital tract outflow obstruction. There is still considerable uncertainty about whether mechanisms such as coelomic metaplasia, embryonic Müllerian rests, or persistence of other forms of embryonic endometriosis are relevant to endometriosis. Mesenchymal stem cells may be the principal source of endometriosis outside the peritoneal cavity. It is possible that progenitor cells play a role also in the pathophysiology of premenarcheal and adolescent endometriosis, since they may originate and implant into the peritoneum as a consequence of retrograde neonatal uterine bleeding.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nBrosens I, Puttemans P, Benagiano G. Endometriosis: a life cycle approach? Am J Obstet Gynecol. 2013;209:307–16.\nvon Recklinghausen F. Die Adenomyomata und Cystadenomata der Uterus und Tubenwandung: Ihre Abkunft von Resten des Wolffischen Körpers [The adenomyomas and cystadenomas of the uterus and tube wall: their origin from remnants of the Wolffian body]. Berlin: August Hirschwald Verlag; 1896.\nKossman R. Die Abstammung der Drüseneinschlüsse in der Uterus und der Tuben [The lineage of the glandular inclusions in the uterus and tubes]. Arch Gynakol. 1897;54:359–81.\nBatt RE, Yeh J. Müllerianosis: four developmental (embryonic) mullerian diseases. Reprod Sci. 2013;20:1030–7.\nMeyer R. Ueber die genese der cystadenome und adenomyome des uterus, mit demonstrationene. Ztschr Geburtsh Gynäkol. 1897;37:327–35.\nHolden FC. Adenomyoma of the uterus. Am J Obstet Gynecol. 1931;22:801.\nSignorile PG, Baldi F, Bussani R, D'Armiento M, De Falco M, Baldi A. Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer. J Exp Clin Cancer Res. 2009;28:49–53.\nBaldi A, Signorile PG. New evidence in endometriosis. Int J Cell Biol Biochem. 2015;60:19–22.\nWolff CF. Theoria generationis [The theory of embryology]. Litteris Hendelianis: Halae ad Salam; 1759.\nMüller J. Bildungsgeschichte der genitalien aus anatomischen untersuchungen an embryonen des menschen und der thiere [History of genital development from anatomical investigations on embryos of man and animals]. Düsseldorf: bei Arnz. 1830;\nSpivack M. Polycystic ovaries in the newborn and early infancy and their relation to the structure of the endometrium. Am J Obstet Gynecol. 1934;27:157–73.\nRobboy SJ, Kurita T, Baskin L, Cunha GR. New insights into human female reproductive tract development. Differentiation. 2017;97:9–22.\nBarberini F, Makabe S, Motta PM. A three-dimensional study of human fetal endocervix with special reference to its epithelium. Histol Histopathol. 1998;13:635–45.\nValdés-Dapena MA. Histology of the fetus and newborn. In: Uterus and vagina. Philadelphia, London, Toronto: W.B. Saunders Company; 1979. p. 479–500.\nRosa P. Endocrinologie sexuelle du fœtus féminin [Sexual endocrinology of the female fetus], vol. 1. Paris, France: Paris: Masson et Cie; 1955. p. 262–72.\nBenagiano G, Brosens I, Habiba M. Adenomyosis: a life-cycle approach. Reprod Biomed Online. 2015;30:220–32.\nOber WB, Bernstein J. Observations on the endometrium and ovary in the newborn. Pediatrics. 1955;16:445–60.\nWang T. Human fetal endometrium – light and electron microscopic study. Arch Gynecol Obstet. 1989;246:169–79.\nBartol FF, Wiley AA, Goodlett DR. Ovine uterine morphogenesis: histochemical aspects of endometrial development in the fetus and neonate. J Anim Sci. 1988;66:1303–13.\nStewart CA, Wang Y, Bonilla-Claudio M, Martin JF, Gonzalez G, Taketo MM, Behringer RR. CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development. Mol Endocrinol. 2013;27:1442–54.\nKelleher AM, DeMayo FJ, Spencer TE. Uterine glands: developmental biology and functional roles in pregnancy. Endocr Rev. 2019;40:1424–45.\nFranco HL, Rubel CA, Large MJ, Wetendorf M, Fernandez-Valdivia R, Jeong JW, Spencer TE, Behringer RR, Lydon JP, DeMayo FJ. Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function. FASEB J. 2012;26:1218–27.\nGray CA, Bartol FF, Tarleton BJ, Wiley AA, Johnson GA, Bazer FW, Spencer TA. Developmental biology of uterine glands. Biol Reprod. 2001;65:1311–23.\nCarus CG. IV. Blut abgang aus den geburts heilen einen neugebornen kindes. [IV Vaginal bleedingin a newborn child]. Zeitschrift fürNatür und Heilkusw. 1822;2:106–7.\nCullingworth CJ. Haemorrhage from the genital organs in the recently born female child. Liverpool and Manchester. Med Surg Rep. 1876;4:48–57.\nHalban J. Über Fetale Menstruation und ihre Bedeutung [On the fetal menstruation and its meaning] Proc Versammlung Deutscher Naturvorscher und Aertze in Breslau (VII.76). Berliner KlinWochenschr. 1904;48:1254–6.\nBrosens I, Benagiano G. The endometrium from the neonate to the adolescent. J Matern Fetal Neonatal Med. 2016;29:1195–9.\nBrosens I, Puttemans P, Benagiano G. Endometriosis: a life cycle approach? Am J Obstet Gynecol. 2013;209:307–16.\nZhang K, Pollack S, Ghods A, Dicken C, Isaac B, Adel G, Zeitlian G, Santoro N. Onset of ovulation after menarche in girls: a longitudinal study. J Clin Endocrinol Metab. 2008;93:1186–94.\nBrosens I, Muter J, Gargett C, Puttemans P, Benagiano G, Brosens JJ. The impact of uterine immaturity on obstetrical syndromes during adolescence. Am J Obstet Gynecol. 2017;217:546–55.\nTulchinsky D, Okada DM. Hormones in human pregnancy. IV. Plasma progesterone. Am J Obstet Gynecol. 1975;121:293–9.\nBrosens I, Ćurčić A, Vejnović T, Gargett CE, Brosens JJ, Benagiano G. The perinatal origins of major reproductive disorders in the adolescent: research avenues. Placenta. 2015b;36:341–4.\nHeller ME, Dewhurst J, Grant DB. Premature menarche without other evidence of precocious puberty. Arch Dis Child. 1979;54:472–5.\nPinto SM, Garden AS. Prepubertal menarche: a defined clinical entity. Am J Obstet Gynecol. 2006;195:327–9.\nHolm K, Laursen EM, Brocks V, Muller J. Pubertal maturation of the internal genitalia: an ultrasound evaluation of 166 healthy girls. Ultrasound Obstet Gynecol. 1995;6:175–81.\nMeyer R. Über adenomatöse Schleimhautwucherungen in der Uterus – und Tubenwand und ihre pathologisch-anatomische Bedeutung [Article in german] On the the adenomatous mucosal growths in the uterus – and tubal wall and their pathological-anatomical features. Virchows Arch Pathol Anat Physiol Klin Med. 1903;172:394–409.\nEmge LA. The elusive adenomyosis of the uterus. Am J Obstet Gynecol. 1962;83:1541–63.\nMeyer R. Ueber epitheliale Gebilde im Myometrium des foetalen und kindlichen uterus einschliesslich des Gartner’schen Ganges. Berlin: Verlag von S. Karger; 1899.\nBouquet De Jolinière J, Ayoubi JM, Gianaroli L, Dubuisson JB, Gogusev J, Feki A. Endometriosis: a new cellular and molecular genetic approach for understanding the pathogenesis and evolutivity. Front Surg. 2014;1:16.\nLauchlan SC. The secondary Müllerian system. Obstet Gynecol Surv. 1972;27:133–46.\nSchuster M, Mackeen DA. Fetal endometriosis: a case report. Fertil Steril. 2015;103:160–2.\nMusina RA, Belyavski AV, Tarusova OV, Solovyova EV, Sukhikh GT. Endometrial mesenchymal stem cells isolated from the menstrual blood. Bull Exp Biol Med. 2008;145:539–43.\nGargett CE, Schwab KE, Deane JA. Endometrial stem/progenitor cells: the first 10 years. Hum Reprod Update. 2016;22:137–63.\nKao AP, Wang KH, Chang CC, et al. Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model. Fertil Steril. 2011;95:1308–15.\nWitz CA, Thomas MR, Montoya-Rodriguez IA, Nair AS, Centonze VE, Schenken RS. Short-term culture of peritoneum explants confirms attachment of endometrium to intact peritoneal mesothelium. Fertil Steril. 2001;75:385–90.\nBrosens I, Brosens JJ, Benagiano G. Neonatal uterine bleeding as an antecedent of pelvic endometriosis. Hum Reprod. 2013;28:2893–7.\nGargett E, Schwab KE, Puttemans P, Brosens JJ, Benagiano G, Brosens I. Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis. Mol Hum Reprod. 2014;20:591–8.\nArcellana RC, Robinson TW, Tyson RW, Joyce MR. McKusick-Kaufman syndrome with legal complications of hydrometrocolpos and congenital endometriosis. J Perinatol. 1996;16:220–3.\nMarsh EE, Laufer MR. Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly. Fertil Steril. 2005;83:758–60.\nEbert AD, Fuhr N, David M, Schneppel L, Papadopoulos T. Histological confirmation of endometriosis in a 9-year-old girl suffering from unexplained cyclic pelvic pain since her eighth year of life. Gynecol Obstet Investig. 2009;67:158–61.\nGogacz M, Sarzynski M, Napierała R, Sierocinska-Sawa J, Semczuk A. Ovarian endometrioma in an 11-year-old girl before menarche: a case study with literature review. J Pediatr Adolesc Gynecol. 2012;25:e5–7.\nTong J, Zhu L, Chen N, Lang J. Endometriosis in association with Herlyn-Werner-Wunderlich syndrome. Fertil Steril. 2014;102:790–4.\nDovey S, Sanfilippo J. Endometriosis and the adolescent. Clin Obstet Gynecol. 2010;53:420–8.\nOlive DL, Henderson DY. Endometriosis and Müllerian anomalies. Obstet Gynecol. 1987;69:412–5.\nYang Y, Wang Y, Yang J, Wang S, Lang J. Adolescent endometriosis in China: a retrospective analysis of 63 cases. J Pediatr Adolesc Gynecol. 2012;25:295–9.\nSanfilippo JS, Wakim NG, Schikler KN, Yussman MA. Endometriosis in association with uterine anomaly. Am J Obstet Gynecol. 1986;154:39–43.\nVasquez G, Cornillie F, Brosens IA. Peritoneal endometriosis: scanning electron microscopy and histology of minimal pelvic endometriotic lesions. Fertil Steril. 1984;42:696–703.\nMurphy AA, Green WR, Bobbie D. Unsuspected endometriosis documented by scanning electron microscopy in visually normal peritoneum. Fertil Steril. 1986;46:522–4.\nWiegerinck MA, Van Dop PA, Brosens IA. The staging of peritoneal endometriosis by the type of active lesion in addition to the revised American Fertility Society classification. Fertil Steril. 1993;60:461–4.\nStripling MC, Martin DC, Chatman DL, Van der Zwaag R, Poston WM. Subtle appearance of pelvic endometriosis. Fertil Steril. 1988;49:427–31.\nMartin DC, Hubert GD, Van der Zwaag R, El-Zeky FA. Laparoscopic appearances of peritoneal endometriosis. Fertil Steril. 1989;51:63–7.\nKalu E, McAuley W, Richardson R. Teenagers, adolescents, endometriosis and recurrence: a retrospective analysis of recurrence following primary operative laparoscopy. Gynecol Surg. 2008;5:209–12.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nHabiba, M., Benagiano, G. (2022). In Utero and Early-Life. In: Oral, E. (eds) Endometriosis and Adenomyosis. Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_11\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-97236-3_11\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-97235-6\nOnline ISBN: 978-3-030-97236-3\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}