The endometrium from the neonate to the adolescent

Ivo Brosens, Jan J. Brosens, Giuseppe Benagiano
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2015 · vol. 29(8) , pp. 1195–1199 · doi:10.3109/14767058.2015.1040756 · PMID:25958988 · W1615955910
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review of neonatal and adolescent endometrium findings links progesterone response variations from birth through adolescence to the origins of endometriosis and major obstetrical syndromes.

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Abstract

BACKGROUND: Scientific data on the phenomenon of uterine bleeding in the neonate (NUB) began to appear over a century ago when angiogenesis and petechial haemorrhages in the endometrium of newborn female infants, as well as fluid blood within the uterine cavity, were first described. METHODS: A thorough search of the 20th century literature was carried out to identify studies reporting data on NUB. RESULTS: The neonatal endometrium, although not identical to the adult, shows cellular responses of the same type, and at birth the endometrium is proliferative in 2/3 of all newborns with the residual 1/3 showing secretory, decidual or menstrual features. In the latter neonates, the presence of a functional cervical obstruction may expose them to menstrual regurgitation including neonatal mesenchymal stem-like cells. This can represent the origin of early-onset endometriosis. At menarche, partial or full ontogenic progesterone resistance can occur in the majority. If persisting, adolescent pregnancy may be exposed to major obstetrical syndromes including preeclampsia and fetal growth restriction. CONCLUSIONS: Increasing evidence indicates that the origin of major reproductive disorders in adolescents may lie in the degree of progesterone response in the neonate. The spectrum of progesterone response from resistance till decidualisation may explain the early occurrence of major obstetrical syndromes and endometriosis, respectively.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometrium Adolescent Endometriosis Endometriosis Endometrium Endometrium Female Fetal Development Humans Infant, Newborn Ovary Ovary Ovary Pregnancy Pregnancy Complications Pregnancy Complications Progesterone Progesterone Uterine Hemorrhage Uterine Hemorrhage

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (7)

Source provenance

europepmc
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openalex
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