Matrix tropism influences endometriotic cell attachment patterns

Theriault, Hannah, Kimmel, Hannah, Alison C. Nunes, Anna Paxhia, Sarah Hashim, Sarfraz Hashim, Kathryn B.H. Clancy, Gregory H. Underhill, Brendan A.C. Harley
In: bioRxiv · 2025 · doi:10.1101/2025.02.22.639314 · PMID:40060608 · W4408007502
preprint OA: green CC0
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study examined how endometriotic cells attach to ovarian matrix components and substrate stiffness, identifying ovarian-specific motifs that increase endometriotic cell attachment, potentially implicating them in early disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Due to the extended period for clinical diagnosis, the etiology of endometriotic lesion initiation is not well understood or characterized. Endometriotic lesions are most often found on pelvic tissues and organs, especially the ovaries. To investigate the role of tissue tropism on ovarian endometrioma initiation, we adapted a well-characterized polyacrylamide microarray system to investigate the role of tissue-specific extracellular matrix and adhesion motifs on endometriotic cell attachment, morphology, and size. We report the influence of cell origin (endometriotic vs. non-endometriotic), substrate stiffness mimicking aging and fibrosis, and the role of multicellular (epithelial-stromal) cohorts on cell attachment patterns. We identify multiple ovarian-specific attachment motifs that significantly increase endometriotic (vs. non-endometriotic) cell cohort attachment that could be implicated in early disease etiology.

My notes (saved in your browser only)

Condition tags

endometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (88)

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK