{"paper_id":"1cb9cef0-1dcd-40d2-98bf-c6952741f64c","body_text":"Abstract\nTheories can be useful in education, guiding research, understanding concepts, postulating physiology, and discussing why therapy might work. However, theory can create a false narrative and should not be used to guide treatment. The inappropriate application of theory to guide medical care can result in the tomato effect or medical reversal.\nA cell of origin is needed to begin any theory of endometriosis. That cell must be accompanied by a method of dissemination (metastasis) or in situ development during embryonic or fetal development or after birth; a force of stimulation, activation, or induction of the transition from a cell of origin to endometriosis; and mechanisms for growth to become endometriosis. Inactivation and clearance can potentially limit the growth.\nResearch should be directed at early events in the development of endometriosis to prevent the development of fibrosis, which may only respond to surgery or natural inactivation. If endometriosis can be controlled or inactivated before it develops into deep infiltrating, ovarian, or severely adhesive disease, surgery may be avoided, or the degree of surgery that is needed may be decreased. Before an early diagnosis is a reasonable goal, we need medical or surgical treatment protocols that are proven to work.\nAccess this chapter\nTax calculation will be finalised at checkout\nPurchases are for personal use only\nSimilar content being viewed by others\nReferences\nMartin DC. Endometriosis concepts and theories 2021. Available: https://www.danmartinmd.com/endoconcepts.html. Accessed 15 Jan 2021.\nWang Y, Nicholes K, Shih IM. The origin and pathogenesis of endometriosis. 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In: Martin DC, editor. Atlas of endometriosis. London: Gower Med Publ; 1993.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG\nAbout this chapter\nCite this chapter\nMartin, D.C. (2022). Pathogenesis of Endometriosis: Theories of the Cells of Origin and Methods of Dissemination. In: Oral, E. (eds) Endometriosis and Adenomyosis. Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_3\nDownload citation\nDOI: https://doi.org/10.1007/978-3-030-97236-3_3\nPublished:\nPublisher Name: Springer, Cham\nPrint ISBN: 978-3-030-97235-6\nOnline ISBN: 978-3-030-97236-3\neBook Packages: MedicineMedicine (R0)","source_license":"CC0","license_restricted":false}