Maria A. Shalina

BACKGROUND: Asymptomatic adenomyosis, which occurs in approximately one-third of patients, is a clinical and scientific enigma, thus being a subject of debate. Practicing physicians face unresolved questions: should they take no action or s…

Background: Timely diagnosis of adenomyosis remains important due to the high incidence of the disease among women of reproductive age. Interest in using myometrial transition zone parameters in diagnostic algorithms has persisted since the…

BACKGROUND: The creation of an experimental model of adenomyosis is of scientific and practical interest, which allows for the evaluation of the effectiveness and pathogenetically substantiated therapy of adenomyosis in the future on the cr…

BACKGROUND: This article presents the second stage of the study to evaluate the efficacy and tolerability of new directions of drug therapy for adenomyosis based on an experimental model of the disease. This stage is necessary for the furth…

BACKGROUND: Previous studies leave no doubt as to the involvement of kisspeptin and oxytocin in the pathogenesis of endometriosis. Oxytocin and kisspeptin levels in the peripheral blood of patients with endometriosis were shown to be higher…

BACKGROUND: The study of stress-induced phosphoprotein 1 in the pathogenesis of adenomyosis is not only of theoretical interest, but this protein may be also considered as a potential biomarker of the disease. AIM: The aim of this study was…

Background. Endometriosis is distinguished by its high prevalence and significant impact on the quality of life and reproductive health of women; however, its etiology and essential pathogenesis of remain uncertain so far. Modern research i…

BACKGROUND: An in-depth study of the pathogenesis of adenomyosis and the development of new therapeutic approaches are extremely relevant. Atosiban, a competitive oxytocin receptor antagonist, may be a promising drug with a potential therap…

This article presents a modern review of the main classifications of adenomyosis based on the clinical course, the prevalence of the pathological process, the results of ultrasound and magnetic resonance imaging, and histological verificati…

The incidence of adenomyosis in young patients who have not realized their reproductive function is steadily increasing, with the tactics of surgical and drug treatment being an unresolved problem. In clinical practice, special attention is…

BACKGROUND: Patients with endometriosis-associated pain syndrome in combination with anxiety or depression have lower treatment effectiveness and satisfaction with both the disease itself and the pain syndrome compared to patients with pain…

BACKGROUND: Adenomyosis is a common gynecological disease with unknown pathogenesis. The HOXA10, HOXA11 and WNT4 genes may play an important role in the pathogenesis of adenomyosis both at the stage of embryonic development and in the postn…

Распространенность аденомиоза не имеет тенденции к снижению, и все чаще это заболевание выявляется у молодых женщин, не осуществивших репродуктивную функцию, в связи с чем необходимо дальнейшее изучение патогенеза аденомиоза, а поиск новых…

BACKGROUND: Ultrasound is widely used in routine practice to diagnose various forms of adenomyosis and uterine fibroids. However, due to the lack of unified criteria, hypo- or overdiagnosis of internal endometriosis is possible. Moreover, t…

BACKGROUND: There are currently no uniform standards for adenomyosis diagnosis, so the search for the most informative methods is an urgent task. This article presents modern views on the diagnosis of adenomyosis and the role of ultrasound …

The article presents modern data on the diagnosis and pathogenetic mechanisms of the development of adenomyosis. Various classifications of the disease are highlighted. The role of genetic and immunological factors in the development of int…

The prevalence of genital endometriosis and adenomyosis, in particular, is tending to increase. The lack of a complete understanding of the pathogenetic mechanisms and multifactorial causes of adenomyosis, the low effectiveness of existing …

Administration of menopausal hormone therapy (MHT) in patients with genital endometriosis (GE) is a controversial issue requiring a patient-personalized approach. Current principles for MHT selection and prescription in patients with anamne…

This review article presents modern data on the diagnosis and pathogenesis of adenomyosis, various classifications of the disease being highlighted. The role of genetic and immunological factors in the development of internal endometriosis …

This article presents a review of the current literature on the impact of such drugs as gonadotropin-releasing hormone agonists, aromatase inhibitors, and dienogest 2 mg, which are used for the treatment of external genital endometriosis, o…