{"paper_id":"f6054afe-a8c9-46b1-81c2-821681a43c48","body_text":"Abstract\nObjective\nThe aim of the present study is to determine the potential risk factors for adenomyosis and to investigate its relationship with accompanying gynecological pathologies and clinical characteristics.\nMaterials and method\nThis study is a retrospective analysis of 945 patients who underwent hysterectomy between May 2005 and January 2013 at the Sifa University Medical Faculty Hospital, Clinic of Obstetrics and Gynecology. The study included 327 patients with adenomyosis and 618 patients without adenomyosis by histopathological examination of the uterus.\nResults\nThere was a significant positive correlation between development of adenomyosis and presence of leiomyoma (p < 0.0001), history of previous abortion (p < 0.0001), history of previous pregnancy (p = 0.0002), and normal body mass index (p < 0.0001). However, no significant relationship existed between development of adenomyosis and smoking (p > 0.4300), normal delivery (p = 0.9600), cesarean delivery (p = 0.5705), endometrial hyperplasia (p = 0.1721), or ovarian endometriosis (p = 0.8595).\nConclusion\nWomen who are multiparous have leiomyoma, a previous history of abortion, and a normal body mass index are at increased risk for development of adenomyosis. Adenomyosis might be one cause of unexplained recurrent spontaneous abortion during pregnancy.\nSimilar content being viewed by others\nReferences\nZaloudek C, Hendrickson MR (2002) Mesenchymal tumors of the uterus. In: Kurman RJ (ed) Blausteins’ pathology of the female genital tract, 5th edn. Springer, New York, pp 561–573\nRabinovici J, Inbar Y, Eylon SC, Schiff E, Hananel A, Freundlich D (2006) Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod 21(5):1255–1259\nParazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG (1997) Risk factors for adenomyosis. Hum Reprod 12(6):1275–1279\nBergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB (2001) Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod 16(11):2418–2421\nKaraer O, Oruç S, Koyuncu FM (2004) Aromatase inhibitors: possible future applications. Acta Obstet Gynecol Scand 83(8):699–706\nBulun SE (2009) Endometriosis. N Engl J Med 360(3):268–279\nParazzini F, Mais V, Cipriani S, Busacca M, Venturini P (2009) Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol 143(2):103–106\nBergeron C, Amant F, Ferenczy A (2006) Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521\nFerenczy A (1998) Pathophysiology of adenomyosis. Hum Reprod Update 4(4):312–322\nKumar V, Cotran R, Robbins SL (1992) Basic Pathology, 5th edn. W.B. Saunders, Philadelphia, pp 615–616\nYeniel O, Cirpan T, Ulukus M, Ozbal A, Gundem G, Ozsener S, Zekioglu O, Yilmaz H (2007) Adenomyosis: prevalence, risk factors, symptoms and clinical findings. Clin Exp Obstet Gynecol. 34(3):163–167\nSaleh SS, Fram K (2012) Histopathology diagnosis in women who underwent a hysterectomy for a benign condition. Arch Gynecol Obstet 285(5):1339–1343\nLevgur M, Abadi MA, Tucker A (2000) Adenomyosis: symptoms, histology, and pregnancy terminations. Obstet Gynecol 95(5):688–691\nTempleman C, Marshall SF, Ursin G, Horn-Ross PL, Clarke CA, Allen M, Deapen D, Ziogas A, Reynolds P, Cress R, Anton-Culver H, West D, Ross RK, Bernstein L (2008) Adenomyosis and endometriosis in the California Teachers Study. Fertil Steril 90(2):415–424\nMartínez-Conejero JA, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simón C, Horcajadas JA, Pellicer A (2011) Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril 96(4):943–950\nJaslow CR (2014) Uterine factors. Obstet Gynecol Clin North Am 41(1):57–86\nYan L, Ding L, Tang R, Chen ZJ (2014) Effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection outcomes in infertile women: a retrospective cohort study. Gynecol Obstet Invest 77(1):14–18\nShrestha A (2012) Risk factors for adenomyosis. J Nepal Health Res Counc. 10(22):229–233\nVercellini P, Vigano P, Somigliana E, Daguati R, Abbiati A, Fedele I (2006) Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol 20:465–477\nDonnez J (2012) Endometriosis: enigmatic in the pathogenesis and controversial in its therapy. Fertil Steril 98(3):509–510\nNovellas S, Chassang M, Delotte J, Toullalan O, Chevallier A, Bouaziz J, Chevallier P (2011) MRI characteristics of the uterine junctional zone: from normal to the diagnosis of adenomyosis. AJR Am J Roentgenol 196(5):1206–1213\nMorelli M, Rocca ML, Venturella R, Mocciaro R, Zullo F (2013) Improvement in chronic pelvic pain after gonadotropin releasing hormone analogue (GnRH-a) administration in premenopausal women suffering from adenomyosis or endometriosis: a retrospective study. Gynecol Endocrinol 29(4):305–308\nConflict of interest\nThis notice is to document that there is no conflict of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nGenc, M., Genc, B. & Cengiz, H. Adenomyosis and accompanying gynecological pathologies. Arch Gynecol Obstet 291, 877–881 (2015). https://doi.org/10.1007/s00404-014-3498-8\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-014-3498-8","source_license":"CC0","license_restricted":false}