Müllerian Adenosarcomas With Unusual Growth Patterns

Blaise Alexander Clarke, Blaise Clarke, Anna Marie Mulligan, Julie A Irving, Julie Irving, W Glenn McCluggage, Esther Oliva
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2011 · vol. 30(4) , pp. 340–347 · doi:10.1097/pgp.0b013e31820b341e · PMID:21623203 · W2029394313
article OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

Uterine adenosarcomas are uncommon mixed Müllerian neoplasms, most commonly arising in the uterine corpus. A new Federation of International Gynecologic Organization staging system for these tumors has recently been implemented. This staging system is an improvement on the earlier generic application of the 1988 Federation of International Gynecologic Organization staging system for endometrial cancer to adenosarcoma. Herein, we report 3 uterine adenosarcomas with unusual features. For 2 of these, no specific staging guidelines are provided by either the earlier or, more importantly, the new staging system. The first case is of an adenosarcoma arising in the eutopic endometrium with involvement of underlying adenomyosis without myometrial invasion; the second originated in a mural adenomyoma in the absence of eutopic endometrial involvement; and the third case encompassed synchronous endometrial and extrauterine (peritoneal) neoplasms. Such cases are rare, and there is insufficient evidence to be definitive about staging. Thus, we suggest a descriptive reporting strategy for adenosarcomas with these unusual features. We also propose a reporting nomenclature for such cases to ensure standardization such that they can be adequately recorded in synoptic reporting protocols. This will facilitate reliable data collection such that an evidence-based staging system for these scenarios may be derived.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenosarcoma Neoplasm Staging Neoplasm Staging Uterine Neoplasms Adenosarcoma Adenosarcoma Adult Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Fallopian Tubes Fallopian Tubes Fallopian Tubes Female Humans Hysterectomy International Cooperation Lymph Nodes Lymph Nodes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (8)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:16:42.478857+00:00
License: CC0 · commercial use OK