Primary Fallopian Tube Mullerian Adenosarcoma With Sarcomatous Overgrowth and a Previously Unreported MEIS1-NCOA2 Gene Fusion

Ribeiro E Ribeiro R, Renan Ribeiro e Ribeiro, Eleanor Lewin, Eleanor R Lewin, Lewin ER, Jesse L Hart, Jesse Hart, Hart JL, Mohammad Ruhul Quddus, Quddus MR, Hansen K, Katrine Hansen
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2021 · vol. 41(1) , pp. 82–85 · doi:10.1097/pgp.0000000000000777 · PMID:33770059 · W3136853290
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A 55-year-old patient with abdominal pain and bloating was found to have a primary fallopian tube Mullerian adenosarcoma with sarcomatous overgrowth and a novel MEIS1-NCOA2 gene fusion.

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Abstract

Extrauterine Mullerian adenosarcomas (MA) are rare and often associated with endometriosis. We report a 55-yr-old patient seen in consultation for abdominal pain and bloating. Imaging was suggestive of a left adnexal mass and "peritoneal carcinomatosis". Pathological examination of the specimen revealed a MA arising in the left fallopian tube, with sarcomatous overgrowth, diffuse peritoneal involvement and omental "caking". Next-generation sequencing identified a MEIS1-NCOA2 gene fusion, previously unreported in MA.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Adenosarcoma Adenosarcoma Fallopian Tube Neoplasms Fallopian Tube Neoplasms Peritoneal Neoplasms Uterine Neoplasms Fallopian Tubes Female Gene Fusion Humans Nuclear Receptor Coactivator 2 Nuclear Receptor Coactivator 2

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References (17)

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