Endometrial Carcinoma Arising in a Large Polypoid Adenomyoma of the Uterus

Saul Kay, Kay S, S Kay, W J Frable, Frable WJ, William J. Frable, D R Goplerud, Dean R. Goplerud, Goplerud DR
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1988 · vol. 7(4) , pp. 391–398 · doi:10.1097/00004347-198812000-00010 · PMID:3068170 · W1996861775
review OA: closed CC0 ⤵ 7 in-corpus citations
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper describes a case of endometrial adenosquamous carcinoma arising within a large intramural adenomyomatous polyp in a 75-year-old woman, which ultimately metastasized to a paraaortic lymph node.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-18 · read from full text ⓘ

This case report describes a 75-year-old woman with endometrial carcinoma developing within a large polypoid adenomyoma. The tumor was identified as a mixed adenosquamous carcinoma embedded in diffuse adenomyomatous infiltration, while the surface endometrium remained atrophic and non-neoplastic. Because the lesion was entirely intramural, the absence of surface involvement resulted in a six-year diagnostic delay before hysterectomy, during which time metastasis to a paraaortic lymph node occurred. This paper is centrally about adenomyosis — specifically illustrating a rare malignant transformation of adenomyomatous tissue into carcinoma without involving the overlying endometrium.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

A case of endometrial carcinoma arising in a large adenomyomatous polyp is described in a 75-year-old woman. The malignant element appeared to be a mixed adenosquamous carcinoma that was embedded in diffuse adenomyomatous infiltration. The lesion was entirely intramural, and the surface endometrium was atrophic and not neoplastic. The absence of endometrial involvement led to a 6-year delay before hysterectomy was carried out. Pathologic study of the radically excised uterus showed evidence of metastasis to one paraaortic lymph node. Since this appears to be the first example of such an event, the English literature was reviewed for the associated findings of adenomyosis and carcinoma in an intramural setting with noninvolvement of the surface endometrium.
Full text 892 characters · extracted from oa-doi-fallback · click to expand
Endometrial Carcinoma Arising in a Large Polypoid Adenomyoma of the Uterus - Saul Kay - W. J. Frable - D. R. Goplerud Summary A case of endometrial carcinoma arising in a large adenomyomatous polyp is described in a 75-year-old woman. The malignant element appeared to be a mixed adenosquamous carcinoma that was embedded in diffuse adenomyomatous infiltration. The lesion was entirely intramural, and the surface endometrium was atrophic and not neoplastic. The absence of endometrial involvement led to a 6-year delay before hysterectomy was carried out. Pathologic study of the radically excised uterus showed evidence of metastasis to one paraaortic lymph node. Since this appears to be the first example of such an event, the English literature was reviewed for the associated findings of adenomyosis and carcinoma in an intramural setting with noninvolvement of the surface endometrium.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma Endometriosis Uterine Neoplasms Adenocarcinoma Aged Endometriosis Female Humans Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (7)

Source provenance

europepmc
last seen: 2026-09-20T09:27:46.357103+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:09:25.758913+00:00
unpaywall
last seen: 2026-09-20T06:29:17.529187+00:00
License: CC0 · commercial use OK