Transvaginale Ultraschalldiagnostik der Adenomyose

In: Gynäkologische Endokrinologie · 2024 · vol. 22(3) , pp. 209–215 · doi:10.1007/s10304-024-00579-w · W4401613424
article OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-13

Transvaginal ultrasound is the preferred first-line imaging method for diagnosing adenomyosis due to its accessibility and cost, with reliability dependent on investigator experience and equipment quality.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text

This paper reviews adenomyosis as a common benign uterine condition and the use of imaging—especially 2D transvaginal ultrasound—to diagnose it because organ-preserving histologic confirmation is not reliably available. It summarizes that transvaginal ultrasound and MRI have comparable diagnostic reliability when performed by experienced investigators, and that sonographic findings can be categorized into direct and indirect signs, with interpretation accuracy depending on examiner training and ultrasound equipment quality. It also notes that the true incidence of adenomyosis remains uncertain because available estimates are based on cohort studies where diagnosis was confirmed by hysterectomy, even though adenomyosis can occur from adolescence to postmenopause. This paper is centrally about adenomyosis—specifically the transvaginal ultrasound diagnostic approach and its reliability relative to MRI.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 15,448 characters · extracted from oa-doi-fallback · click to expand
Zusammenfassung Die Adenomyose ist eine häufige gutartige Erkrankung der Gebärmutter, die bei den meisten betroffenen Frauen Symptome wie Dysmenorrhö, Dyspareunie, Unterbauchschmerzen und Blutungsstörungen verursachen kann. Sie hat einen ungünstigen Einfluss auf die Fertilität, führt zu höheren Abortraten, zu niedrigeren Erfolgsraten bei künstlicher Befruchtung und kann geburtshilfliche Komplikationen wie vorzeitigen Blasensprung, Frühgeburtlichkeit, Plazentationsstörungen, Uterusruptur sowie fetale Wachstumsretardierungen verursachen. Die genaue Inzidenz der Adenomyose ist unklar, und die vorhandenen Daten hierzu stammen aus Kohortenstudien, in denen die Diagnose mittels Hysterektomie gesichert wurde. Die Adenomyose tritt aber von der Adoleszenz bis zur Postmenopause auf. Wegen fehlender zuverlässiger Methoden der organerhaltenden histologischen Sicherung wird die Diagnose anhand bildgebender Verfahren gestellt. Liegen transvaginale Sonographie und Magnetresonanztomographie in den Händen geübter UntersucherInnen, sind sie hinsichtlich der diagnostischen Zuverlässigkeit vergleichbar. Die Ultraschalldiagnostik, insbesondere die 2‑dimensionale transvaginale Sonographie, ist aufgrund der besseren Verfügbarkeit und der geringeren Kosten die diagnostische Methode der ersten Wahl. Die in der Literatur beschriebenen sonographisch sichtbaren Veränderungen des Uterus werden in direkte und indirekte Zeichen unterteilt. Die Zuverlässigkeit der Befundung ist vom Ausbildungsstand der UntersucherInnen und von der technischen Qualität des Ultraschallgeräts abhängig. Abstract Adenomyosis is a frequent benign uterine condition, which can cause symptoms, such as dysmenorrhea, dyspareunia, lower abdominal pain and bleeding disorders in most affected women. Adenomyosis is related to a negative impact on fertility with higher abortion rates and lower success rates in assisted reproduction and it can cause obstetrical complications, such as premature rupture of membranes, premature birth, placentation failure, uterine rupture and fetal growth retardation. The exact incidence of adenomyosis remains uncertain as the available data are based on cohort studies in which the diagnosis was confirmed by hysterectomy; however, adenomyosis can occur from adolescence up to the postmenopausal epoch. Due to the lack of reliable methods of obtaining histological samples without damaging organs, the diagnosis is made based on imaging procedures. In the hands of experienced investigators magnetic resonance imaging (MRI) and transvaginal ultrasound are comparable with respect to the diagnostic reliability. Due to its relatively low cost and accessibility, ultrasound diagnostics and in particular two-dimensional transvaginal sonography represent the first-line imaging approach. The sonographically visible alterations to the uterus described in the literature are divided into direct and indirect signs. The reliability of the interpretation of the results depends on the individual experience of the investigator and the technical quality of the ultrasound scanner. Similar content being viewed by others Literatur Krentel H, Cezar C, Becker S, Di Spiezio Sardo A, Tanos V, Wallwiener M, De Wilde RL (2017) From clinical symptoms to MR imaging: diagnostic steps in adenomyosis. Biomed Res Int 2017:1514029 Ferrero S, Camerini G, Menada MV, Biscaldi E, Ragni N, Remorgida V (2009) Uterine adenomyosis in persistence of dysmenorrhea after surgical excision of pelvic endometriosis and colorectal resection. J Reprod Med 54(6):366–372 Younes G, Tulandi T (2017) Effects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis. Fertil Steril 108(3):483–490 Pados G, Gordts S, Sorrentino F, Nisolle M, Nappi L, Daniilidis A (2023) Adenomyosis and infertility: a literature review. Medicina 59(9):1551. https://doi.org/10.3390/medicina59091551 Alson S, Jokubkiene L, Henic E, Sladkevicius P (2024) Prevalence of adenomyosis features in women scheduled for assisted reproductive treatment, using the Morphological Uterus Sonographic Assessment group definitions. Acta Obstet Gynecol Scand. https://doi.org/10.1111/aogs.14812 Buggio L, Monti E, Gattei U, Dridi D, Vercellini P (2017) Adenomyosis: fertility and obstetric outcome. A comprehensive literature review. Minerva Ginecol. https://doi.org/10.23736/S0026-4784.17.04163-6 Hashimoto A, Iriyama T, Sayama S, Okamura A, Kato K, Fujii T, Kubota K, Ichinose M, Sone K, Kumasawa K, Nagamatsu T, Hirota Y, Osuga Y (2023) Differences in the incidence of obstetric complications depending on the extent and location of adenomyosis lesions. J Matern Fetal Neonatal Med 36(2):2226789. https://doi.org/10.1080/14767058.2023.2226789 Dueholm M (2017) Uterine adenomyosis and infertility, review of reproductive outcome after in vitro fertilization and surgery. Acta Obstet Gynecol Scand 96(6):715–726 Tamura H, Kishi H, Kitade M, Asai-Sato M, Tanaka A, Murakami T, Minedishi T, Sugino N (2017) Clinical outcomes of infertility treatment for women with adenomyosis in Japan. Reprod Med Biol 16(3):276–282 Moawad G, Fruscalzo A, Youssef Y, Kheil M, Tawil T, Nehme J, Pirtea P, Guani B, Afaneh H, Ayoubi JM, Feki A (2023) Adenomyosis: An Updated Review on Diagnosis and Classification. J Clin Med 12(14):4828. https://doi.org/10.3390/jcm12144828 Exacoustos C, Morosetti G, Conway F, Camilli S, Martire FG, Lazzeri L, Piccione E, Zupi E (2020) New sonographic classification of adenomyosis: do type and degree of adenomyosis correlate to severity of symptoms? J Minim Invasive Gynecol 27(6):1308–1315. https://doi.org/10.1016/j.jmig.2019.09.788 Kobayashi H, Imanaka S (2024) Understanding ultrasound features that predict symptom severity in patients with adenomyosis: a systematic review. Reprod Sci 31(2):320–331. https://doi.org/10.1007/s43032-023-01318-5 Bourdon M, Oliveira J, Marcellin L, Santulli P, Bordonne C, Maitrot Mantelet L, Millischer AE, Plu Bureau G, Chapron C (2021) Adenomyosis of the inner and outer myometrium are associated with different clinical profiles. Hum Reprod 36(2):349–357. https://doi.org/10.1093/humrep/deaa307 Graziano A, Lo Monte G, Piva I, Caserta D, Karner M, Engl B, Marci R (2015) Diagnostic findings in adenomyosis: a pictorial review on the major concerns. Eur Rev Med Pharmacol Sci 19(7):1146–1154 Tellum T, Nygaard S, Lieng M (2020) Noninvasive diagnosis of adenomyosis: a structured review and meta-analysis of diagnostic accuracy in imaging. J Minim Invasive Gynecol 27(2):408–418.e3 Bazot M, Darai E (2018) Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis. Fertil Steril 109(3):389–397 Andres MP, Borelli GM, Ribeiro J, Baracat EC, Abrao MS, Kho RM (2018) Transvaginal ultrasound for the diagnosis of adenomyosis: systematic review and meta-analysis. J Minim Invasive Gynecol 25(2):257–264 Jain S, Kumar K, Shukla RC, Jain M (2023) Diagnostic role of transvaginal sonography and magnetic resonance imaging in adenomyosis of the uterus and its correlation with histopathology. J Midlife Health 14(1):34–41. https://doi.org/10.4103/jmh.jmh_230_22 Krentel H, Keckstein J, Füger T, Hornung D, Theben J, Salehin D, Buchweitz O, Mueller A, Schäfer SD, Sillem M, Schweppe KW, Tchartchian G, Gilman E, De Wilde RL (2023) Accuracy of ultrasound signs on two-dimensional transvaginal ultrasound in prediction of adenomyosis: prospective multicenter study. Ultrasound Obstet Gynecol 62(5):739–746. https://doi.org/10.1002/uog.26197 Liu L, Li W, Leonardi M, Condous G, Da Silva Costa F, Mol BW, Wong L (2021) Diagnostic accuracy of transvaginal ultrasound and magnetic resonance imaging for adenomyosis: systematic review and meta-analysis and review of Sonographic diagnostic criteria. J Ultrasound Med 40(11):2289–2306. https://doi.org/10.1002/jum.15635 Dartmouth K (2014) A systematic review with meta-analysis: the common sonographic characteristics of adenomyosis. Ultrasound 22(3):148–157. https://doi.org/10.1177/1742271X14528837 Di Donato N, Bertoldo V, Montanari G, Zannoni L, Caprara G, Seracchioli R (2015) Question mark form of uterus: a simple sonographic sign associated with the presence of adenomyosis. Ultrasound Obstet Gynecol 46(1):126–127. https://doi.org/10.1002/uog.14750 Harmsen MJ, Trommelen LM, de Leeuw RA, Tellum T, Juffermans LJM, Griffioen AW, Thomassin-Naggara I, Van den Bosch T, Huirne JAF (2023) Uterine junctional zone and adenomyosis: comparison of MRI, transvaginal ultrasound and histology. Ultrasound Obstet Gynecol 62(1):42–60. https://doi.org/10.1002/uog.26117 Rasmussen CK, Hansen ES, Ernst E, Dueholm M (2019) Two- and three-dimensional transvaginal ultrasonography for diagnosis of adenomyosis of the inner myometrium. Reprod Biomed Online 38(5):750–760. https://doi.org/10.1016/j.rbmo.2018.12.033 Van den Bosch T, Dueholm M, Leone FP, Valentin L, Rasmussen CK, Votino A, Van Schoubroeck D, Landolfo C, Installé AJ, Guerriero S, Exacoustos C, Gordts S, Benacerraf B, D´Hooghe T, De Moor B, Brölmann H, Goldstein S, Epstein E, Bourne T, Timmerman D (2015) Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group. Ultrasound Obstet Gynecol 46(3):284–298 Harmsen MJ, Van den Bosch T, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, Hehenkamp WJK, Groenman F, De Bruyn C, Rasmussen C, Lazzeri L, Jokubkiene L, Jurkovic D, Naftalin J, Tellum T, Bourne T, Timmerman D, Huirne JAF (2022) Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure. Ultrasound Obstet Gynecol 60(1):118–131. https://doi.org/10.1002/uog.24786 Sam M, Raubenheimer M, Manolea F, Aguilar H, Mathew RP, Patel VH, Low G (2020) Accuracy of findings in the diagnosis of uterine adenomyosis on ultrasound. Abdom Radiol 45(3):842–850. https://doi.org/10.1007/s00261-019-02231-9 Sinha S, Agarwal M, Bhadani PP, Roy R, Sinha U (2023) Development and validation of sonological classification and scoring system for uterine adenomyosis: A pilot study. F1000Res 11:1138. https://doi.org/10.12688/f1000research.125700.2 Exacoustos C, Brienza L, Di Giovanni A, Szabolcs B, Romanini ME, Zupi E, Arduini D (2011) Adenomyosis: three-dimensional sonographic findings of the junctional zone and correlation with histology. Ultrasound Obstet Gynecol 37(4):471–479. https://doi.org/10.1002/uog.8900 Moliner B, Llacer J, Sellers F, Castillo JC, Fuentes A, Bernabeu A, Bernabeu R (2021) 4D ultrasound as a method to assess uterine peristalsis. Fertil Steril 116(1):272–274. https://doi.org/10.1016/j.fertnstert.2021.02.017 Guo SW, Benagiano G, Bazot M (2022) In search of an imaging classification of adenomyosis: a role for elastography? J Clin Med 12(1):287. https://doi.org/10.3390/jcm12010287 Ren Q, Dong X, Yuan M, Jiao X, Sun H, Pan Z, Wang X, Tao G, Guoyun W (2023) Application of elastography to diagnose adenomyosis and evaluate the degree of dysmenorrhea: a prospective observational study. Reprod Biol Endocrinol 21(1):98. https://doi.org/10.1186/s12958-023-01145-y Benagiano G, Brosens I, Habiba M (2015) Adenomyosis: a life-cycle approach. Reprod Biomed Online 30(3):220–232 Bazot M, Cortez A, Darai E, Rouger J, Chopier J, Antoine JM, Uzan S (2001) Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. Hum Reprod 16(11):2427–2433 Tellum T, Nygaard S, Lieng M (2020) Noninvasive diagnosis of adenomyosis: a structured review and meta-analysis of diagnostic accuracy in imaging. J Minim Invasive Gynecol 27(2):408–418.e3. https://doi.org/10.1016/j.jmig.2019.11.001 Vannuccini S, Meleca C, Toscano F, Mertino P, Pampaloni F, Fambrini M, Bruni V, Petraglia F (2023) Adenomyosis diagnosis among adolescents and young women with dysmenorrhoea and heavy menstrual bleeding. Reprod Biomed Online 48(5):103768. https://doi.org/10.1016/j.rbmo.2023.103768 Exacoustos C, Lazzeri L, Martire FG, Russo C, Martone S, Centini G, Piccione E, Zupi E (2022) Ultrasound findings of adenomyosis in adolescents: type and grade of the disease. J Minim Invasive Gynecol 29(2):291–299.e1. https://doi.org/10.1016/j.jmig.2021.08.023 Timmerman S, Stubbe L, Van den Bosch T, Van Schoubroeck D, Tellum T, Froyman W (2024) Accessory cavitated uterine malformation (ACUM): a scoping review. Acta Obstet Gynecol Scand. https://doi.org/10.1111/aogs.14801 Varras M, Polyzos D, Akrivis Ch (2003) Effects of tamoxifen on the human female genital tract: review of the literature. Eur J Gynaecol Oncol 24(3–4):258–268 Boes AS, Tousseyn T, Vandenput I, Timmerman D, Vergote I, Moerman P, Amant F (2011) Pitfall in the diagnosis of endometrial cancer: case report of an endometrioid adenocarcinoma arising from uterine adenomyosis. Eur J Gynaecol Oncol 32(4):431–434 Habiba M, Pluchino N, Petignat P, Bianchi P, Brosens IA, Benagiano G (2018) Adenomyosis and endometrial cancer: literature review. Gynecol Obstet Invest 83(4):313–328. https://doi.org/10.1159/000487320 Keckstein J, Hoopmann M, Merz E, Grab D, Weichert J, Helmy-Bader S, Wölfler M, Bajka M, Mechsner S, Schäfer S, Krentel H, Hudelist G (2023) Expert opinion on the use of transvaginal sonography for presurgical staging and classification of endometriosis. Arch Gynecol Obstet 307(1):5–19. https://doi.org/10.1007/s00404-022-06766-z Ren Q, Yuan M, Wang G (2024) Role of ultrasonography in the evaluation of disease severity and treatment efficacy in adenomyosis. Arch Gynecol Obstet 309(2):363–371. https://doi.org/10.1007/s00404-023-07034-4 Torres-de la Roche LA, Rafiq S, Devassy R, Verhoeven HC, Becker S, De Wilde RL (2022) Should ultrasound-guided high frequency focused ultrasound be considered as an alternative non-surgical treatment of uterine fibroids in non-asiatic countries? An opinion paper. J Clin Med 11(3):839. https://doi.org/10.3390/jcm11030839 Chen Y, Lin S, Xie X, Yi J, Liu X, Guo SW (2024) Systematic review and meta-analysis of reproductive outcomes after high-intensity focused ultrasound (HIFU) treatment of adenomyosis. Best Pract Res Clin Obstet Gynaecol 92:102433. https://doi.org/10.1016/j.bpobgyn.2023.102433 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt H. Krentel, A. Constantin, A. Naem, K. Otto, D. Andrikos und R.L. De Wilde geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information Redaktion Annette Bachmann, Frankfurt Ludwig Kiesel, Münster Petra Stute, Bern Hinweis des Verlags Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral. QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Krentel, H., Constantin, A., Naem, A. et al. Transvaginale Ultraschalldiagnostik der Adenomyose. Gynäkologische Endokrinologie 22, 209–215 (2024). https://doi.org/10.1007/s10304-024-00579-w Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10304-024-00579-w Schlüsselwörter - Zweidimensionaler transvaginaler Ultraschall - Transvaginaler Ultraschall/Untersuchererfahrung - Dysmenorrhö - Endometriose - Blutungsstörungen

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (40)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-04T02:00:05.705006+00:00
License: CC0 · commercial use OK