A History of Adenomyosis

Some 150 years ago, pathologists identified “mucosal invasions” in peritoneal organs. The term “adenomyoma” was coined to refer to these epithelial lesions and the surrounding smooth muscle and stroma. Early descriptions featured rare and unusual presentations, but it became increasingly apparent that the presence of ectopic mucosa is relatively frequent. Similarity to endometrial mucosa was readily recognized, but extensive debate followed about the nature and origin of these “mucosal invasions”; many refused this interpretation. Only around 1920, their “endometrial nature” became widely accepted. Central to this was the work of Thomas Cullen, who provided detailed accounts of lesions located within various pelvic structures. At the same time, few pioneers questioned whether “adenomyomas” represent only one type of lesion. Oskar Frankl coined the name “adenomyosis” to distinguish “endometrial nests” deep in the myometrium from other affections. This marked the “genesis” of a new disease and the recognition of its clinical significance. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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