Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

Ayako Hashimoto, Takayuki Iriyama, Seisuke Sayama, Toshio Nakayama, Atsushi Komatsu, Akito Miyauchi, Osamu Nishii, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2017 · vol. 31(3) , pp. 364–369 · doi:10.1080/14767058.2017.1285895 · PMID:28110584 · W2582200713
article OA: closed CC0 ⤵ 99 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that adenomyosis is associated with significantly higher risks of second trimester miscarriage, preeclampsia, placental malposition, and preterm delivery compared to pregnancies without adenomyosis.

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Abstract

OBJECTIVE: To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. METHODS: We performed a retrospective case-control study. Forty-nine singleton pregnancy cases complicated with adenomyosis were included in this study. The controls (n = 245) were singleton pregnant women without adenomyosis and were frequency matched to adenomyosis cases by age, parity, and the need for assisted reproductive technology for this conception. The incidence of obstetrical complications and delivery and neonatal outcomes were examined. RESULTS: Patients in the adenomyosis group were significantly more likely to have a second trimester miscarriage (12.2% versus 1.2%, odds ratio (OR): 11.2, 95% confidence interval (95% CI): 2.2-71.2), preeclampsia (18.3% versus 1.2%, OR: 21.0, 95% CI: 4.8-124.5), placental malposition (14.2% versus 3.2%, OR: 4.9, 95% CI: 1.4-16.3), and preterm delivery (24.4% versus 9.3%, OR: 3.1, 95% CI: 1.2-7.2), compared with the control group. CONCLUSION: Adenomyosis was associated not only with an increased incidence of preterm delivery, as previously reported, but also with an increased risk of second trimester miscarriage, preeclampsia, and placental malposition, which could lead to poor perinatal outcomes.

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Condition tags

adenomyosis

MeSH descriptors

Abortion, Spontaneous Adenomyosis Pre-Eclampsia Abortion, Spontaneous Abortion, Spontaneous Adenomyosis Adult Female Humans Japan Japan Placenta Previa Placenta Previa Placenta Previa Pre-Eclampsia Pre-Eclampsia Pregnancy Pregnancy Trimester, Second Premature Birth Premature Birth

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References (23)

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