Endometriosis Increases the Risk of Placenta Previa in Both IVF Pregnancies and the General Obstetric Population

Eider Gómez-Pereira, Jorge Burgos, Rosario Mendoza, Irantzu Pérez-Ruiz, Fátima Olaso, David García, Iker Malaina, Roberto Matorras
Reproductive sciences (Thousand Oaks, Calif.) · 2022 · vol. 30(3) , pp. 854–864 · doi:10.1007/s43032-022-01054-2 · PMID:35999442 · W4292849666
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Endometriosis is associated with a significantly higher risk of placenta previa in both IVF pregnancies and the general obstetric population, even after adjusting for other factors.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective study used prospectively recorded data from two Cruces University Hospital databases to examine whether endometriosis is associated with placenta previa (PP) in both an assisted reproduction techniques (ART) population and a general obstetric population, using cesarean deliveries and a matched subset design in the obstetric cohort. Across ART cesarean sections, PP rates were higher in women with endometriosis than without endometriosis (including an adjusted analysis), and similar increased PP rates were observed in the general obstetric cesarean cohort; endometriosis remained associated with higher PP risk after adjusting for age, IVF, multiplicity, and previous deliveries. In the PP cesarean subgroup, surgical time and hospital stay were significantly higher in women with endometriosis. This paper is centrally about endometriosis — it reports that endometriosis increases the risk of placenta previa in both IVF/ART and the general obstetric population, and does not specifically discuss adenomyosis.

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Abstract

Is there a relationship between endometriosis and placenta previa (PP)? To investigate if there is a relationship between endometriosis and PP, a retrospective study was carried out, using prospectively recorded data from two different databases from Cruces University Hospital. Two different populations were included in the study. The ART (assisted reproduction techniques) population consisted of 246 cesarean sections (CS), from a total of 1170 deliveries, and the obstetric population consisted of 7045 CS, from a total of 50,298 deliveries. A representative subset from the obstetric population was established selecting 4 CS without PP for each CS with PP. In our ART population, the PP rate was 1.71% among all deliveries and 8.13% among CS. In our general obstetric population, the PP rate was 0.34% among all deliveries and 2.41% among the CS. Among the CS in ART pregnancies, the PP rate was 20% in the women with endometriosis vs 5.47% in women without endometriosis (OR = 4.32; 95% CI = 1.67-11.17), while considering all ART deliveries, the PP rates were 6.43% and 1.07%, respectively (OR = 6.36; 95% CI = 2.59-15.65). In the CS-obstetric population, the rate of PP was 9.61% among women with endometriosis vs 2.19% among women without endometriosis (OR = 4.74; 95% CI = 2.91-7.73). Considering all deliveries, the PP rate was 1.35% among women with endometriosis vs 0.30% in women without endometriosis. Differences persisted when adjusting for age, IVF, multiplicity, and previous deliveries. In the CS-obstetric population with PP, mean surgical time and hospital stay were significantly higher in women with endometriosis. Endometriosis is associated with a higher risk of PP even after adjusting for other parameters.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Placenta Previa Placenta Previa Placenta Previa Placenta Previa

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