Endometriosis Increases the Risk of Placenta Previa in Both IVF Pregnancies and the General Obstetric Population

Is there a relationship between endometriosis and placenta previa (PP)? To investigate if there is a relationship between endometriosis and PP, a retrospective study was carried out, using prospectively recorded data from two different databases from Cruces University Hospital. Two different populations were included in the study. The ART (assisted reproduction techniques) population consisted of 246 cesarean sections (CS), from a total of 1170 deliveries, and the obstetric population consisted of 7045 CS, from a total of 50,298 deliveries. A representative subset from the obstetric population was established selecting 4 CS without PP for each CS with PP. In our ART population, the PP rate was 1.71% among all deliveries and 8.13% among CS. In our general obstetric population, the PP rate was 0.34% among all deliveries and 2.41% among the CS. Among the CS in ART pregnancies, the PP rate was 20% in the women with endometriosis vs 5.47% in women without endometriosis (OR = 4.32; 95% CI = 1.67–11.17), while considering all ART deliveries, the PP rates were 6.43% and 1.07%, respectively (OR = 6.36; 95% CI = 2.59–15.65). In the CS-obstetric population, the rate of PP was 9.61% among women with endometriosis vs 2.19% among women without endometriosis (OR = 4.74; 95% CI = 2.91–7.73). Considering all deliveries, the PP rate was 1.35% among women with endometriosis vs 0.30% in women without endometriosis. Differences persisted when adjusting for age, IVF, multiplicity, and previous deliveries. In the CS-obstetric population with PP, mean surgical time and hospital stay were significantly higher in women with endometriosis. Endometriosis is associated with a higher risk of PP even after adjusting for other parameters. Similar content being viewed by others Data Availability Available upon request. Code Availability Not applicable.

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Horizontal cervix as a novel sign for predicting adhesions on the posterior extrauterine wall in cases of placenta previa. J Clin Med. 2019. https://doi.org/10.3390/jcm8122141. Author information Authors and Affiliations Contributions E Gómez-Pereira: data collection and management, protocol development, data analysis, and manuscript writing. J Burgos: data collection and manuscript editing. R Mendoza: data collection and manuscript editing. I Pérez-Ruiz: data analysis and manuscript writing and editing. D García: data collection and management and manuscript editing. F Olaso: data collection and management and manuscript editing. I Malaina: data analysis and manuscript editing. R Matorras: protocol and project development and manuscript writing and editing. Corresponding author Ethics declarations Ethics Approval The study project was approved by the Clinical Research Ethics Committee (CEIC) of Cruces University Hospital on 25 February 2020, with CEIC code E20/11. Consent to Participate Informed consent was obtained from all patients for being included in the study (CEIC E20/11). Consent for Publication As above. Conflict of Interest The authors declare no competing interests. Rights and permissions Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Gómez-Pereira, E., Burgos, J., Mendoza, R. et al. Endometriosis Increases the Risk of Placenta Previa in Both IVF Pregnancies and the General Obstetric Population. Reprod. Sci. 30, 854–864 (2023). https://doi.org/10.1007/s43032-022-01054-2 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s43032-022-01054-2