Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

Ayako Hashimoto, Hashimoto A, Takayuki Iriyama, Iriyama T, Seisuke Sayama, Sayama S, Nakayama T, Toshio Nakayama, Atsushi Komatsu, Komatsu A, Akito Miyauchi, Miyauchi A, Nishii O, Osamu Nishii, Nagamatsu T, Takeshi Nagamatsu, Osuga Y, Yutaka Osuga, Tomoyuki Fujii, Fujii T
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2017 · vol. 31(3) , pp. 364–369 · doi:10.1080/14767058.2017.1285895 · PMID:28110584 · W2582200713
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This study found that adenomyosis is associated with significantly higher risks of second trimester miscarriage, preeclampsia, placental malposition, and preterm delivery compared to pregnancies without adenomyosis.

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Abstract

OBJECTIVE: To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. METHODS: We performed a retrospective case-control study. Forty-nine singleton pregnancy cases complicated with adenomyosis were included in this study. The controls (n = 245) were singleton pregnant women without adenomyosis and were frequency matched to adenomyosis cases by age, parity, and the need for assisted reproductive technology for this conception. The incidence of obstetrical complications and delivery and neonatal outcomes were examined. RESULTS: Patients in the adenomyosis group were significantly more likely to have a second trimester miscarriage (12.2% versus 1.2%, odds ratio (OR): 11.2, 95% confidence interval (95% CI): 2.2-71.2), preeclampsia (18.3% versus 1.2%, OR: 21.0, 95% CI: 4.8-124.5), placental malposition (14.2% versus 3.2%, OR: 4.9, 95% CI: 1.4-16.3), and preterm delivery (24.4% versus 9.3%, OR: 3.1, 95% CI: 1.2-7.2), compared with the control group. CONCLUSION: Adenomyosis was associated not only with an increased incidence of preterm delivery, as previously reported, but also with an increased risk of second trimester miscarriage, preeclampsia, and placental malposition, which could lead to poor perinatal outcomes.

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Condition tags

adenomyosis

MeSH descriptors

Abortion, Spontaneous Adenomyosis Pre-Eclampsia Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Adenomyosis Adenomyosis Adult Adult Female Female Humans Humans Japan Japan Japan Placenta Previa Placenta Previa Placenta Previa

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Cited by (50)

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