Fertility, Pregnancy Rate, and Neonatal Outcome of Patient with Adenomyosis

In: European Journal of Medical and Health Sciences · 2022 · vol. 4(5) , pp. 120–124 · doi:10.24018/ejmed.2022.4.5.1386 · W4307708322
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Adenomyosis is associated with decreased pregnancy rates and increased miscarriage rates after ART, along with higher risks of preeclampsia, premature delivery, and other adverse neonatal outcomes.

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This paper systematically reviewed 17 observational studies (searching MEDLINE, PubMed, and Cochrane up to April 2022) evaluating how adenomyosis affects fertility, assisted reproductive technology (ART) outcomes, and neonatal and obstetric complications. Across ART, adenomyosis was associated with a reduced clinical pregnancy rate (OR 0.69, 95% CI 0.51–0.94) and an increased miscarriage rate (OR 2.17, 95% CI 1.25–3.79), with the lower pregnancy rate particularly evident in studies using shorter GnRH downregulation regimens; similar patterns were reported after age adjustment. Adenomyosis was also linked to higher risks of preeclampsia, premature delivery, cesarean section, fetal malpresentation, small-for-gestational-age infants, and postpartum hemorrhage after adjustments for age and mode of conception. The paper’s main caveat is that the evidence comes from observational studies. This paper is centrally about adenomyosis and its effects on fertility, pregnancy outcomes, and neonatal outcomes.

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Abstract

This study aimed to look at the link between adenomyosis and fertility, pregnancy, and neonatal outcomes. Until April 2022, an electronic search was conducted utilizing the Medline, Pubmed, and Cochrane databases. There were seventeen observational studies in total. After assisted reproductive technology, adenomyosis was linked to a reduced clinical pregnancy rate (OR 0.69; 95 percent CI 0.51, 0.94) and a greater miscarriage rate (OR 2.17; 95 percent CI 1.25, 3.79) (ART). The lower clinical pregnancy rate was more substantial in the subset of individuals with brief downregulation regimens. Similar relationships were seen after age adjustment. Preeclampsia, premature delivery, cesarean section, fetal malpresentation, small-for-gestational-age infancy, and postpartum hemorrhage were also substantially linked to adenomyosis, which was confirmed after adjusting for age and mode of conception. Finally, adenomyosis is a disease that affects the muscles.
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Fertility, Pregnancy Rate, and Neonatal Outcome of Patient with Adenomyosis Article Main Content This study aimed to look at the link between adenomyosis and fertility, pregnancy, and neonatal outcomes. Until April 2022, an electronic search was conducted utilizing the Medline, Pubmed, and Cochrane databases. There were seventeen observational studies in total. After assisted reproductive technology, adenomyosis was linked to a reduced clinical pregnancy rate (OR 0.69; 95 percent CI 0.51, 0.94) and a greater miscarriage rate (OR 2.17; 95 percent CI 1.25, 3.79) (ART). The lower clinical pregnancy rate was more substantial in the subset of individuals with brief downregulation regimens. Similar relationships were seen after age adjustment. Preeclampsia, premature delivery, cesarean section, fetal malpresentation, small-for-gestational-age infancy, and postpartum hemorrhage were also substantially linked to adenomyosis, which was confirmed after adjusting for age and mode of conception. 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